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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

BCAT2  -  branched chain amino-acid transaminase 2,...

Homo sapiens

Synonyms: BCAM, BCAT(m), BCATM, BCT2, Branched-chain-amino-acid aminotransferase, mitochondrial, ...
 
 
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High impact information on BCAT2

  • Aminotransferase activity of placental origin PP18 antigens was verified by structural analysis and by a coupled branched-chain aminotransferase/glutamate dehydrogenase assay [1].
  • Five different insert-length cDNAs encoding for soluble placental tissue protein 18 (PP18) variants were isolated by screening a human placental cDNA library using monospecific anti-PP18 serum [1].
  • Finally, the nomenclature BCAT1 for the cytosolic gene and BCAT2 for the mitochondrial BCAT gene is proposed [2].
  • Isolation and characterization of four new placental tissue proteins (PP18, PP19, PP20, PP21) [3].
 

Biological context of BCAT2

 

Analytical, diagnostic and therapeutic context of BCAT2

  • We detected the two PP18 variants in normal adult and fetal human tissues besides the mitochondrial (only PP18a) and cytosolic (only PP18b) fractions of term placenta with chemiluminescence Western blot analysis [1].

References

  1. Molecular cloning and characterization of placental tissue protein 18 (PP18a)/human mitochondrial branched-chain aminotransferase (BCATm) and its novel alternatively spliced PP18b variant. Than, N.G., Sümegi, B., Than, G.N., Bellyei, S., Bohn, H. Placenta (2001) [Pubmed]
  2. Cloning of the rat and human mitochondrial branched chain aminotransferases (BCATm). Bledsoe, R.K., Dawson, P.A., Hutson, S.M. Biochim. Biophys. Acta (1997) [Pubmed]
  3. Isolation and characterization of four new placental tissue proteins (PP18, PP19, PP20, PP21). Bohn, H., Winckler, W. Arch. Gynecol. (1985) [Pubmed]
  4. Branched-chain aminotransferase deficiency in Chinese hamster cells complemented by two independent genes on human chromosomes 12 and 19. Naylor, S.L., Shows, T.B. Somatic Cell Genet. (1980) [Pubmed]
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