High impact information on BAT1

• An overview of the layered controls of the extended leucine pathway is provided that includes a description of the newly recognized roles of Ilv5p and Bat1p in maintaining mitochondrial integrity [1].
• Both Bat proteins show striking similarity to the mammalian protein Eca39, which is one of the few known targets of the myc oncogene [2].
• However, the promoter region of the yeast ECA39 harbors several Gcn4 binding elements [3].
• The tissue specific expression of human ECA39 during embryogenesis is similar to that of the mouse homolog [3].
• First of all, as propanol is synthesised from alpha-ketobutyrate, the first metabolic intermediate in the anabolic pathway of isoleucine, neither the eca39 nor eca40 mutations have any effect on the production of this higher alcohol [4].

Biological context of BAT1

• The data show that, with the exception of a slow growth phenotype observed for the BAT1 deletion strain, the fermentation behaviour of the strains was unaffected by the modifications [5].

Associations of BAT1 with chemical compounds

• We found that the LEU1, LEU2, and BAT1 genes were up-regulated in TFL20 for metabolism, and that TFL20 simultaneously produced as much i-AmOH and leucine as K30 does [6].

References