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Gene Review

robo2  -  roundabout, axon guidance receptor,...

Danio rerio

Synonyms: SO:0000704
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High impact information on robo2

  • Retinal ganglion cells express robo2 as they extend axons [1].
  • Missorting in box can be rescued by overexpression of extl3. dak;box double mutants show synthetic pathfinding phenotypes that phenocopy robo2 mutants, suggesting that Robo2 function requires HS in vivo; however, tract sorting does not require Robo function, since it is normal in robo2 null mutants [2].
  • In the astray/robo2 mutant, growth cones are larger and more complex than wild-type. astray axons make midline errors not seen in wild-type, as well as errors both before and after the midline. astray errors are rarely corrected [3].
  • In the robo2 mutant, astray (ast), early growing olfactory axons misroute ventromedially or posteriorly, and often penetrate into the diencephalon without reaching the OB primordium [4].


  1. astray, a zebrafish roundabout homolog required for retinal axon guidance. Fricke, C., Lee, J.S., Geiger-Rudolph, S., Bonhoeffer, F., Chien, C.B. Science (2001) [Pubmed]
  2. Axon sorting in the optic tract requires HSPG synthesis by ext2 (dackel) and extl3 (boxer). Lee, J.S., von der Hardt, S., Rusch, M.A., Stringer, S.E., Stickney, H.L., Talbot, W.S., Geisler, R., Nüsslein-Volhard, C., Selleck, S.B., Chien, C.B., Roehl, H. Neuron (2004) [Pubmed]
  3. Pathfinding and error correction by retinal axons: the role of astray/robo2. Hutson, L.D., Chien, C.B. Neuron (2002) [Pubmed]
  4. Robo2 is required for establishment of a precise glomerular map in the zebrafish olfactory system. Miyasaka, N., Sato, Y., Yeo, S.Y., Hutson, L.D., Chien, C.B., Okamoto, H., Yoshihara, Y. Development (2005) [Pubmed]
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