The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ROBO2  -  roundabout, axon guidance receptor,...

Homo sapiens

Synonyms: KIAA1568, Roundabout homolog 2
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ROBO2


High impact information on ROBO2


Biological context of ROBO2

  • Sciatic transection resulted in a significant up-regulation of both Robo2 and Slit1 mRNA and protein (p<0.05 versus control) [1].

Anatomical context of ROBO2

  • Robo1 and Robo2 cooperate to control the guidance of major axonal tracts in the mammalian forebrain [5].
  • Our results indicate that Slit1 and Robo2 likely play an important role in regeneration after peripheral nerve injury [1].

Other interactions of ROBO2

  • SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site [6].
  • The putative receptors for Slits, robo1 and robo2, are expressed in the inner retinal layer in which RGCs are located [7].

Analytical, diagnostic and therapeutic context of ROBO2

  • By contrast, injury to the central axons of the DRG by dorsal rhizotomy did not up-regulate Slit1 and Robo2 expression [1].


  1. Dynamic changes in Robo2 and Slit1 expression in adult rat dorsal root ganglion and sciatic nerve after peripheral and central axonal injury. Yi, X.N., Zheng, L.F., Zhang, J.W., Zhang, L.Z., Xu, Y.Z., Luo, G., Luo, X.G. Neurosci. Res. (2006) [Pubmed]
  2. The migration of cerebellar rhombic lip derivatives. Gilthorpe, J.D., Papantoniou, E.K., Chédotal, A., Lumsden, A., Wingate, R.J. Development (2002) [Pubmed]
  3. Slit and Robo control cardiac cell polarity and morphogenesis. Qian, L., Liu, J., Bodmer, R. Curr. Biol. (2005) [Pubmed]
  4. Familial vesicoureteral reflux: testing replication of linkage in seven new multigenerational kindreds. Sanna-Cherchi, S., Reese, A., Hensle, T., Caridi, G., Izzi, C., Kim, Y.Y., Konka, A., Murer, L., Scolari, F., Ravazzolo, R., Ghiggeri, G.M., Gharavi, A.G. J. Am. Soc. Nephrol. (2005) [Pubmed]
  5. Robo1 and Robo2 cooperate to control the guidance of major axonal tracts in the mammalian forebrain. López-Bendito, G., Flames, N., Ma, L., Fouquet, C., Di Meglio, T., Chedotal, A., Tessier-Lavigne, M., Marín, O. J. Neurosci. (2007) [Pubmed]
  6. SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Grieshammer, U., Le Ma, n.u.l.l., Plump, A.S., Wang, F., Tessier-Lavigne, M., Martin, G.R. Dev. Cell (2004) [Pubmed]
  7. Slit2 is a repellent for retinal ganglion cell axons. Niclou, S.P., Jia, L., Raper, J.A. J. Neurosci. (2000) [Pubmed]
WikiGenes - Universities