Disease relevance of ROBO2

• Dynamic changes in Robo2 and Slit1 expression in adult rat dorsal root ganglion and sciatic nerve after peripheral and central axonal injury [1].

High impact information on ROBO2

• Later born granule cell precursors also migrate ventrally but halt at the lateral edge of the cerebellum, correlating with a loss of sensitivity to netrin 1 and expression of Robo2 [2].
• Similar phenotypes are observed when Robo and Robo2 are manipulated [3].
• Previous studies in humans have also suggested loci on chromosomes 6p21, 10q26, and 19q13, whereas mutations in ROBO2 were recently reported in some patients with VUR [4].
• In conclusion, we report an altered expression and redistribution of Robo2 and Slit1 in the DRG and sciatic nerve trunk after peripheral axotomy [1].
• In the present study, we examined expression of Slit1 and Robo2 in adult rat dorsal root ganglion (DRG), spinal cord and sciatic nerve after peripheral nerve injury (axotomy) [1].

Biological context of ROBO2

• Sciatic transection resulted in a significant up-regulation of both Robo2 and Slit1 mRNA and protein (p<0.05 versus control) [1].

Anatomical context of ROBO2

• Robo1 and Robo2 cooperate to control the guidance of major axonal tracts in the mammalian forebrain [5].
• Our results indicate that Slit1 and Robo2 likely play an important role in regeneration after peripheral nerve injury [1].

Other interactions of ROBO2

• SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site [6].
• The putative receptors for Slits, robo1 and robo2, are expressed in the inner retinal layer in which RGCs are located [7].

Analytical, diagnostic and therapeutic context of ROBO2

• By contrast, injury to the central axons of the DRG by dorsal rhizotomy did not up-regulate Slit1 and Robo2 expression [1].

References