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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Diencephalon


Psychiatry related information on Diencephalon


High impact information on Diencephalon


Chemical compound and disease context of Diencephalon


Biological context of Diencephalon

  • I suggest that a Valsalva manoeuvre, blocking venous return through the superior vena cava, may allow brief retrograde transmission of high venous pressure from the arms to the cerebral venous system, resulting in venous ischaemia to the diencephalon or mesial temporal lobes and to TGA [16].
  • Quantitative autoradiographic localization of prostaglandin E2 binding sites in monkey diencephalon [17].
  • We tested whether normal Pax-6 protein is required for early diencephalic development by examining morphology, precursor proliferation and patterns of regulatory gene expression in the embryonic diencephalon of Small-eye mice (Pax-6 mutants) [18].
  • Furthermore, Otx2 under the AN enhancer cooperates with Emx2 in diencephalon development [19].
  • To determine whether the phenotype results from loss of GAP-43 in RGCs or in diencephalon components such as CD44/SSEA axons, wild-type, heterozygous, or homozygous GAP-43 null donor retinal tissues were grafted onto host diencephalons of all three genotypes, and graft axon growth into the optic tract region was assessed [20].

Anatomical context of Diencephalon


Associations of Diencephalon with chemical compounds


Gene context of Diencephalon

  • The transcription factor Pax6 is widely expressed throughout the developing nervous system, including most alar regions of the newly formed murine diencephalon [31].
  • Emx2 directs the development of diencephalon in cooperation with Otx2 [32].
  • We present evidence that Fgf15 shows Shh-dependent expression in the diencephalon and may participate in this interaction, at least in part, by regulating the ability of dorsal neural precursors to respond to dorsally secreted Wnt mitogens [33].
  • In the diencephalon of the mutant, Bmp4 expression is maintained, whereas Fgf8 expression is not detectable [34].
  • Msx1 is required for dorsal diencephalon patterning [35].

Analytical, diagnostic and therapeutic context of Diencephalon


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  12. A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. Heisenberg, C.P., Houart, C., Take-Uchi, M., Rauch, G.J., Young, N., Coutinho, P., Masai, I., Caneparo, L., Concha, M.L., Geisler, R., Dale, T.C., Wilson, S.W., Stemple, D.L. Genes Dev. (2001) [Pubmed]
  13. The homeodomain protein vax1 is required for axon guidance and major tract formation in the developing forebrain. Bertuzzi, S., Hindges, R., Mui, S.H., O'Leary, D.D., Lemke, G. Genes Dev. (1999) [Pubmed]
  14. Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning. Karlstrom, R.O., Talbot, W.S., Schier, A.F. Genes Dev. (1999) [Pubmed]
  15. Experimental studies on central benzodiazepine receptors in the brains of hepatic encephalopathy rats. Zhang, Z.M., Chen, X.P., Qiu, F.Z. Chin. Med. J. (1993) [Pubmed]
  16. Aetiology of transient global amnesia. Lewis, S.L. Lancet (1998) [Pubmed]
  17. Quantitative autoradiographic localization of prostaglandin E2 binding sites in monkey diencephalon. Watanabe, Y., Watanabe, Y., Hayaishi, O. J. Neurosci. (1988) [Pubmed]
  18. Roles of Pax-6 in murine diencephalic development. Warren, N., Price, D.J. Development (1997) [Pubmed]
  19. Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm. Kurokawa, D., Takasaki, N., Kiyonari, H., Nakayama, R., Kimura-Yoshida, C., Matsuo, I., Aizawa, S. Development (2004) [Pubmed]
  20. Retinal ganglion cell axon progression from the optic chiasm to initiate optic tract development requires cell autonomous function of GAP-43. Kruger, K., Tam, A.S., Lu, C., Sretavan, D.W. J. Neurosci. (1998) [Pubmed]
  21. Regionalization of the optic tectum: combinations of gene expression that define the tectum. Nakamura, H. Trends Neurosci. (2001) [Pubmed]
  22. The mouse Nkx-1.2 homeobox gene: alternative RNA splicing at canonical and noncanonical splice sites. Rovescalli, A.C., Cinquanta, M., Ferrante, J., Kozak, C.A., Nirenberg, M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  23. Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon. Qiu, Y., Cooney, A.J., Kuratani, S., DeMayo, F.J., Tsai, S.Y., Tsai, M.J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  24. SHOT, a SHOX-related homeobox gene, is implicated in craniofacial, brain, heart, and limb development. Blaschke, R.J., Monaghan, A.P., Schiller, S., Schechinger, B., Rao, E., Padilla-Nash, H., Ried, T., Rappold, G.A. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  25. Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes, is expressed in migrating neurons of the CNS. Bulfone, A., Menguzzato, E., Broccoli, V., Marchitiello, A., Gattuso, C., Mariani, M., Consalez, G.G., Martinez, S., Ballabio, A., Banfi, S. Hum. Mol. Genet. (2000) [Pubmed]
  26. Negative regulatory elements upstream of a novel exon of the neuronal nicotinic acetylcholine receptor alpha 2 subunit gene. Bessis, A., Savatier, N., Devillers-Thiéry, A., Bejanin, S., Changeux, J.P. Nucleic Acids Res. (1993) [Pubmed]
  27. Fgf19 regulated by Hh signaling is required for zebrafish forebrain development. Miyake, A., Nakayama, Y., Konishi, M., Itoh, N. Dev. Biol. (2005) [Pubmed]
  28. Close juxtapositions between luteinizing hormone-releasing hormone-immunoreactive neurons and corticotropin-releasing factor-immunoreactive axons in the human diencephalon. Dudás, B., Merchenthaler, I. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  29. Close juxtapositions between LHRH immunoreactive neurons and substance P immunoreactive axons in the human diencephalon. Dudás, B., Merchenthaler, I. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  30. Topography and associations of leu-enkephalin and luteinizing hormone-releasing hormone neuronal systems in the human diencephalon. Dudás, B., Merchenthaler, I. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  31. A role for Pax6 in the normal development of dorsal thalamus and its cortical connections. Pratt, T., Vitalis, T., Warren, N., Edgar, J.M., Mason, J.O., Price, D.J. Development (2000) [Pubmed]
  32. Emx2 directs the development of diencephalon in cooperation with Otx2. Suda, Y., Hossain, Z.M., Kobayashi, C., Hatano, O., Yoshida, M., Matsuo, I., Aizawa, S. Development (2001) [Pubmed]
  33. A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo. Ishibashi, M., McMahon, A.P. Development (2002) [Pubmed]
  34. Formation of Rathke's pouch requires dual induction from the diencephalon. Takuma, N., Sheng, H.Z., Furuta, Y., Ward, J.M., Sharma, K., Hogan, B.L., Pfaff, S.L., Westphal, H., Kimura, S., Mahon, K.A. Development (1998) [Pubmed]
  35. Msx1 is required for dorsal diencephalon patterning. Bach, A., Lallemand, Y., Nicola, M.A., Ramos, C., Mathis, L., Maufras, M., Robert, B. Development (2003) [Pubmed]
  36. Ectopic induction and reorganization of Wnt-1 expression in quail/chick chimeras. Bally-Cuif, L., Wassef, M. Development (1994) [Pubmed]
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