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Gene Review

wnt3a  -  wingless-type MMTV integration site family...

Danio rerio

Synonyms: SO:0000704, Zwnt[a], wnt3, wnt3 l, wnt3l, ...
 
 
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High impact information on wnt3l

  • These data place sp5l downstream of wnt3a and wnt8 in a Wnt/beta-catenin signaling pathway that controls tail development in zebrafish [1].
  • In embryos injected with wnt3a and wnt8 morpholinos, expression of genes in undifferentiated presomitic mesoderm is initiated, but not maintained [1].
  • In zebrafish, wnt3a and wnt8 are expressed in overlapping domains in the blastoderm margin and later in the tailbud [2].
  • The combined inhibition of Wnt3a and Wnt8 by antisense morpholino oligonucleotides led to anteriorization of the neuroectoderm, expansion of the dorsal organizer, and loss of the posterior body structure-a more severe phenotype than with inhibition of each Wnt alone-indicating a redundant role for Wnt3a and Wnt8 [2].

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