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Gene Review

sp5l  -  Sp5 transcription factor-like

Danio rerio

Synonyms: SO:0000704, Spr2, YF-335, cb577, fc23b01, ...
 
 
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High impact information on sp5l

  • In contrast, morpholino- mediated knockdown of Spr2 activity inhibits ntl expression and reduces the inductive effect of Fgfs on ntl [1].
  • An SP1-like transcription factor Spr2 acts downstream of Fgf signaling to mediate mesoderm induction [1].
  • These data place sp5l downstream of wnt3a and wnt8 in a Wnt/beta-catenin signaling pathway that controls tail development in zebrafish [2].
  • To identify genes that might function downstream of Wnts in tail formation, a DNA microarray screen was conducted, revealing that sp5l, a member of the Sp1 family of zinc-finger transcription factors, is activated by Wnt signaling [2].
  • Taken together, these data suggest that sp5l mediates the functions of Fgf signals in anteroposterior patterning of the neuroectoderm during zebrafish embryogenesis [3].

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