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Gene Review:

CYP71A10 - cytochrome P450 71A10

Glycine max

Siminszky, B. et al.

Siminszky, Corbin, Ward, Fleischmann, Dewey,

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High impact information on CYP71A10

In vitro enzyme assays showed that the gene product of one heterologously expressed P450 cDNA (CYP71A10) specifically catalyzed the metabolism of phenylurea herbicides, converting four herbicides of this class (fluometuron, linuron, chlortoluron, and diuron) into more polar compounds [1].
Analyses of the metabolites suggest that the CYP71A10 encoded enzyme functions primarily as an N-demethylase with regard to fluometuron, linuron, and diuron, and as a ring-methyl hydroxylase when chlortoluron is the substrate [1].

Associations of CYP71A10 with chemical compounds

For linuron and chlortoluron, CYP71A10-mediated herbicide metabolism resulted in significantly enhanced tolerance to these compounds in the transgenic plants [1].

References

Expression of a soybean cytochrome P450 monooxygenase cDNA in yeast and tobacco enhances the metabolism of phenylurea herbicides. Siminszky, B., Corbin, F.T., Ward, E.R., Fleischmann, T.J., Dewey, R.E. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]

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