Disease relevance of Cotoran

• Toxicity of cotoran (fluometuron) in Desert sheep [1].
• Cotoran poisoning was characterized by grinding of the teeth, ruminal tympany, mydriasis, dyspnea, staggering, paresis of the hind and forelimbs, and recumbency [1].

High impact information on Cotoran

• Analyses of the metabolites suggest that the CYP71A10 encoded enzyme functions primarily as an N-demethylase with regard to fluometuron, linuron, and diuron, and as a ring-methyl hydroxylase when chlortoluron is the substrate [2].
• Defluorination of the trifluoromethyl group in FLX and in fluometuron and flutalanil,two other compounds containing this functional group, is suggested to be a common direct photolysis pathway for trifluoromethylated compounds [3].
• During the second season of monitoring, pesticide half-lives were significantly reduced, with fluometuron exhibiting a half-life of 13.8 days, aldicarb 6.2 days and endosulfan 7.5 days in the open pond [4].
• Laboratory studies assessed the potential of soils to degrade and sorb atrazine and fluometuron within a recently constructed wetland [5].
• The release kinetics were fitted to the generalized model for up to 60% release of fluometuron; the kinetics of fluometuron were of the anomalous type for all matrixes in which release rates increased following a delay [6].

Biological context of Cotoran

• Effects of fluometuron on embryonic development and hatching of Fasciola hepatica's Miracidia [7].

Associations of Cotoran with other chemical compounds

• Effects of the herbicides fluometuron and prometryn of Rhizoctonia solani in soil cultures [8].
• Metabolism in human embryonic lung cell cultures of three phenylurea herbicides: chlorotoluron, fluometuron, and metobromuron [9].
• After optimisation of the IDA intensity threshold for the detection of tiny chromatographic peaks in noise, five out of the eight compounds (milrinone, lorazepam, fluometuron, piretanide and warfarin) could be unambiguously identified at the concentration of 0.1 mg/l in serum, in the positive or negative modes, or in both, versus only two by LC-MS [10].

References