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Chemical Compound Review

Cortoran     1,1-dimethyl-3-[3- (trifluoromethyl)phenyl]...

Synonyms: Cotogard, Cottenex, Cottonex, Cotoran, Pakhtaran, ...
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Disease relevance of Cotoran


High impact information on Cotoran

  • Analyses of the metabolites suggest that the CYP71A10 encoded enzyme functions primarily as an N-demethylase with regard to fluometuron, linuron, and diuron, and as a ring-methyl hydroxylase when chlortoluron is the substrate [2].
  • Defluorination of the trifluoromethyl group in FLX and in fluometuron and flutalanil,two other compounds containing this functional group, is suggested to be a common direct photolysis pathway for trifluoromethylated compounds [3].
  • During the second season of monitoring, pesticide half-lives were significantly reduced, with fluometuron exhibiting a half-life of 13.8 days, aldicarb 6.2 days and endosulfan 7.5 days in the open pond [4].
  • Laboratory studies assessed the potential of soils to degrade and sorb atrazine and fluometuron within a recently constructed wetland [5].
  • The release kinetics were fitted to the generalized model for up to 60% release of fluometuron; the kinetics of fluometuron were of the anomalous type for all matrixes in which release rates increased following a delay [6].

Biological context of Cotoran


Associations of Cotoran with other chemical compounds


  1. Toxicity of cotoran (fluometuron) in Desert sheep. Mohamed, O.S., Ahmed, K.E., Adam, S.E., Idris, O.F. Veterinary and human toxicology. (1995) [Pubmed]
  2. Expression of a soybean cytochrome P450 monooxygenase cDNA in yeast and tobacco enhances the metabolism of phenylurea herbicides. Siminszky, B., Corbin, F.T., Ward, E.R., Fleischmann, T.J., Dewey, R.E. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  3. Aqueous photochemical reaction kinetics and transformations of fluoxetine. Lam, M.W., Young, C.J., Mabury, S.A. Environ. Sci. Technol. (2005) [Pubmed]
  4. Pesticide removal from cotton farm tailwater by a pilot-scale ponded wetland. Rose, M.T., Sanchez-Bayo, F., Crossan, A.N., Kennedy, I.R. Chemosphere (2006) [Pubmed]
  5. Laboratory assessment of atrazine and fluometuron degradation in soils from a constructed wetland. Weaver, M.A., Zablotowicz, R.M., Locke, M.A. Chemosphere (2004) [Pubmed]
  6. Controlled release of the herbicide, fluometuron, from matrix granules based on fractionated organosolv lignins. Zhao, J., Wilkins, R.M. J. Agric. Food Chem. (2003) [Pubmed]
  7. Effects of fluometuron on embryonic development and hatching of Fasciola hepatica's Miracidia. Christian, F.A., Tate, T.M. Bulletin of environmental contamination and toxicology. (1982) [Pubmed]
  8. Effects of the herbicides fluometuron and prometryn of Rhizoctonia solani in soil cultures. Beam, H.W., Curl, E.A., Rodriguez-Kabana, R. Can. J. Microbiol. (1977) [Pubmed]
  9. Metabolism in human embryonic lung cell cultures of three phenylurea herbicides: chlorotoluron, fluometuron, and metobromuron. Lin, T.H., Menzer, R.E., North, H.H. J. Agric. Food Chem. (1976) [Pubmed]
  10. Comparison of a preliminary procedure for the general unknown screening of drugs and toxic compounds using a quadrupole-linear ion-trap mass spectrometer with a liquid chromatography-mass spectrometry reference technique. Marquet, P., Saint-Marcoux, F., Gamble, T.N., Leblanc, J.C. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2003) [Pubmed]
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