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Gene Review:

RORB - RAR-related orphan receptor B

Homo sapiens

Synonyms: NR1F2, Nuclear receptor ROR-beta, Nuclear receptor RZR-beta, Nuclear receptor subfamily 1 group F member 2, ROR-BETA, ...

Sumi, Y. et al., Agez, L. et al., Stehlin-Gaon, C. et al., Srinivas, M. et al., André, E. et al.

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High impact information on RORB

All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta [1].
Our results identify ROR beta as a retinoid-regulated nuclear receptor, providing a novel pathway for retinoid action [1].
We report that the orphan nuclear receptor RORbeta (retinoid-related orphan receptor beta) activates the S opsin gene (Opn1sw) through binding sites upstream of the gene [2].
5. Results clearly showed that, while roralpha was not affected by melatonin, the hormone partially prevented the decrease of the rorbeta mRNA expression observed in control animals during the first hours following the injection [3].
A novel isoform of the orphan nuclear receptor RORbeta is specifically expressed in pineal gland and retina [4].

Anatomical context of RORB

Rhythmic expression of ROR beta mRNA in the mice suprachiasmatic nucleus [5].

Analytical, diagnostic and therapeutic context of RORB

The expression of the brain rich orphan nuclear receptor ROR beta (retinoid-related orphan receptor beta) was investigated in the mouse brain by in situ hybridization using antisense cRNA probe [5].

References

All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta. Stehlin-Gaon, C., Willmann, D., Zeyer, D., Sanglier, S., Van Dorsselaer, A., Renaud, J.P., Moras, D., Schüle, R. Nat. Struct. Biol. (2003) [Pubmed]
Activation of the blue opsin gene in cone photoreceptor development by retinoid-related orphan receptor beta. Srinivas, M., Ng, L., Liu, H., Jia, L., Forrest, D. Mol. Endocrinol. (2006) [Pubmed]
Melatonin affects nuclear orphan receptors mRNA in the rat suprachiasmatic nuclei. Agez, L., Laurent, V., P??vet, P., Masson-P??vet, M., Gauer, F. Neuroscience (2007) [Pubmed]
A novel isoform of the orphan nuclear receptor RORbeta is specifically expressed in pineal gland and retina. André, E., Gawlas, K., Becker-André, M. Gene (1998) [Pubmed]
Rhythmic expression of ROR beta mRNA in the mice suprachiasmatic nucleus. Sumi, Y., Yagita, K., Yamaguchi, S., Ishida, Y., Kuroda, Y., Okamura, H. Neurosci. Lett. (2002) [Pubmed]

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AgaP_AGAP009002	Anopheles gambiae str. PEST
RORB	Bos taurus
nhr-23	Caenorhabditis elegans
RORB	Canis lupus familiaris
rorb	Danio rerio
Hr46	Drosophila melanogaster
RORB	Gallus gallus
RORB	Macaca mulatta
Rorb	Mus musculus
RORB	Pan troglodytes
Rorb	Rattus norvegicus
rorb	Xenopus (Silurana) tropicalis

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