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Gene Review

Rorb  -  RAR-related orphan receptor beta

Mus musculus

Synonyms: Nr1f2, Nuclear receptor ROR-beta, Nuclear receptor RZR-beta, Nuclear receptor subfamily 1 group F member 2, RZR-beta, ...
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High impact information on Rorb


Biological context of Rorb

  • In neuronal cells, GaI-RZR beta fusion proteins function as potent transcriptional activators, whereas no transactivation can be observed in nonneuronal cells [2].
  • The amino acid sequence of ROR gamma exhibits a 50 and 51% identity with those of ROR alpha/RZR alpha and RZR beta, respectively, whereas the DNA-binding domains were 89% identical [5].

Anatomical context of Rorb

  • In addition, we discover that transcription factor Rorb is down-regulated in the barrelless mutant relative to control mice by quantitative comparison of expression patterns in layer IV somatosensory cortex [6].

Associations of Rorb with chemical compounds

  • Mutational analyses demonstrate that the activation domain (AF-2) of RZR beta and RAR alpha are functionally interchangeable [2].


  1. Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice. André, E., Conquet, F., Steinmayr, M., Stratton, S.C., Porciatti, V., Becker-André, M. EMBO J. (1998) [Pubmed]
  2. Functional analysis of retinoid Z receptor beta, a brain-specific nuclear orphan receptor. Greiner, E.F., Kirfel, J., Greschik, H., Dörflinger, U., Becker, P., Mercep, A., Schüle, R. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  3. Activation of the blue opsin gene in cone photoreceptor development by retinoid-related orphan receptor beta. Srinivas, M., Ng, L., Liu, H., Jia, L., Forrest, D. Mol. Endocrinol. (2006) [Pubmed]
  4. The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily. Paravicini, G., Steinmayr, M., André, E., Becker-André, M. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  5. ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle. Hirose, T., Smith, R.J., Jetten, A.M. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  6. A digital atlas to characterize the mouse brain transcriptome. Carson, J.P., Ju, T., Lu, H.C., Thaller, C., Xu, M., Pallas, S.L., Crair, M.C., Warren, J., Chiu, W., Eichele, G. PLoS Comput. Biol. (2005) [Pubmed]
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