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Gene Review

Opn1sw  -  opsin 1 (cone pigments), short-wave...

Mus musculus

Synonyms: AW551857, BOP, Bcp, Blue Cone Opsin, Blue Opsin, ...
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Disease relevance of Opn1sw

  • By contrast, temporal and spatial expression of Pou4f2 and Pax6 in developing ganglion and amacrine cells and PNA and blue opsin in developing cone cells was relatively normal in the mutant [1].
  • Pancreatic cancer was induced by treatment with 40 mg/kg body wt N-nitrosobis-(2-oxopropyl)amine (BOP) [2].
  • Furthermore, the incidence of BOP-induced gall bladder adenocarcinoma was elevated in cabbage-fed hamsters irrespective of dietary fat intake [2].
  • Feeding cabbage in the high fat diet elevated the yield of BOP-induced pancreatic ductular carcinoma (1.6 carcinomas/effective animal) in comparison with that observed in hamsters fed cabbage in a low fat diet or in those given a high fat diet without cabbage, 0.6-0.8 carcinomas/effective animal (P less than 0.05) [2].

High impact information on Opn1sw

  • Here, we show that S opsin transcription is higher than that of M opsin, which supports ultraviolet (UV) sensitivity greater than midwavelength sensitivity [3].
  • In Nrl-/- retinas, the GFP+ photoreceptors express S-opsin, consistent with the transformation of rod precursors into cones [4].
  • The first transgenic model expressed a murine cone pigment, S-opsin, together with the endogenous rhodopsin in the rod cell [5].
  • Western blot analysis with a hamster anti-BOP mAb have detected the BOP protein in muscle cells and in COS 7 cells transfected with Bop cDNA constructs [6].
  • The BOP proteins expressed in CTLs and muscle contain zinc finger-like motifs with homology to those of the ETO/MTG8 proto-oncogene and several other proteins of interest [6].

Chemical compound and disease context of Opn1sw


Biological context of Opn1sw


Anatomical context of Opn1sw


Associations of Opn1sw with chemical compounds

  • [D-Pro10]Dyn A-(2-11) was prepared by solid phase synthesis using Fmoc-protected amino acids, and the tyrosine derivatives were coupled to the peptide with BOP ((benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate) [13].
  • Alternatively, certain target compounds 3 were synthesized by reaction of 7 with appropriately functionalized glycine precursors under Schotten-Bauman or BOP chloride condensation conditions to provide C-5 acylamino intermediates, followed by Red-Al reduction and deprotection steps [14].
  • BOPP also chelates paramagnetic ions such as Mn(2+), and therefore its tissue accumulation and selectivity can be detected noninvasively by using magnetic resonance imaging [15].
  • One week after birth, Crj:CD-1 mice of both sexes were subcutaneously administered N-nitrosobis(2-oxopropyl)amine (BOP) at a dose of 50 mg/kg as an initiation treatment and starting 2 weeks thereafter they were fed diets supplemented with MeIQx at concentrations of 300, 30, 3 or 0 ppm or PhIP at 200, 50, 10 or 0 ppm for 23 weeks [16].

Regulatory relationships of Opn1sw

  • The results identify Opn1sw as a target gene for RORbeta and suggest a key role for RORbeta in regulating opsin expression in the color visual system [8].
  • Binding of endogenous TH to TRbeta2 is required to inhibit S-opsin and to activate M-opsin [17].

Other interactions of Opn1sw

  • Here we show that exogenous TH inhibits S-opsin expression, but activates M-opsin expression [17].
  • Using opsin antibodies and a sensitive detection protocol, we here show that S opsin immunoreactivity colocalizes with M opsin immunoreactivity in a common type of cone photoreceptor [10].
  • Thus, Grk1 is essential to normal inactivation of both S- and M-mouse cone opsins, but S-opsin has access to a relatively effective, Grk1-independent inactivation pathway [18].
  • These results suggested that even though the number of cones expressing S-opsin is increased, the physiological function of the S-cone system is not enhanced in rd7 mice [19].

Analytical, diagnostic and therapeutic context of Opn1sw

  • Cabbage was fed from before carcinogen treatment in low fat diet and, beginning 1 week after BOP treatment, cabbage was given in low fat and high fat diets in comparison with the respective non-cabbage-containing diets [2].
  • PKC-positive cones are found primarily in the ventral retina, and double-label immunocytochemistry using a short wavelength-sensitive opsin antibody confirms that they specifically correspond to the UVWS cone subtype [20].
  • Employing microarray and in situ hybridization analysis we have found that the rd7 retina contains a modestly increased number of S-opsin-expressing cells that ultrastructurally appear to be normal cones [21].


  1. Delayed expression of the Crx gene and photoreceptor development in the Chx10-deficient retina. Rutherford, A.D., Dhomen, N., Smith, H.K., Sowden, J.C. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  2. Enhanced pancreatic and skin tumorigenesis in cabbage-fed hamsters and mice. Birt, D.F., Pelling, J.C., Pour, P.M., Tibbels, M.G., Schweickert, L., Bresnick, E. Carcinogenesis (1987) [Pubmed]
  3. The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning. Applebury, M.L., Antoch, M.P., Baxter, L.C., Chun, L.L., Falk, J.D., Farhangfar, F., Kage, K., Krzystolik, M.G., Lyass, L.A., Robbins, J.T. Neuron (2000) [Pubmed]
  4. Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors. Akimoto, M., Cheng, H., Zhu, D., Brzezinski, J.A., Khanna, R., Filippova, E., Oh, E.C., Jing, Y., Linares, J.L., Brooks, M., Zareparsi, S., Mears, A.J., Hero, A., Glaser, T., Swaroop, A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  5. Light causes phosphorylation of nonactivated visual pigments in intact mouse rod photoreceptor cells. Shi, G.W., Chen, J., Concepcion, F., Motamedchaboki, K., Marjoram, P., Langen, R., Chen, J. J. Biol. Chem. (2005) [Pubmed]
  6. The Bop gene adjacent to the mouse CD8b gene encodes distinct zinc-finger proteins expressed in CTLs and in muscle. Hwang, I., Gottlieb, P.D. J. Immunol. (1997) [Pubmed]
  7. Antitumor effects of analogs of LH-RH and somatostatin: experimental and clinical studies. Schally, A.V., Srkalovic, G., Szende, B., Redding, T.W., Janaky, T., Juhasz, A., Korkut, E., Cai, R.Z., Szepeshazi, K., Radulovic, S. J. Steroid Biochem. Mol. Biol. (1990) [Pubmed]
  8. Activation of the blue opsin gene in cone photoreceptor development by retinoid-related orphan receptor beta. Srinivas, M., Ng, L., Liu, H., Jia, L., Forrest, D. Mol. Endocrinol. (2006) [Pubmed]
  9. Sequences and evolution of human and squirrel monkey blue opsin genes. Shimmin, L.C., Mai, P., Li, W.H. J. Mol. Evol. (1997) [Pubmed]
  10. A mouse-like retinal cone phenotype in the Syrian hamster: S opsin coexpressed with M opsin in a common cone photoreceptor. Glösmann, M., Ahnelt, P.K. Brain Res. (2002) [Pubmed]
  11. Retinoid X receptor (gamma) is necessary to establish the S-opsin gradient in cone photoreceptors of the developing mouse retina. Roberts, M.R., Hendrickson, A., McGuire, C.R., Reh, T.A. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  12. The primordial, blue-cone color system of the mouse retina. Haverkamp, S., Wässle, H., Duebel, J., Kuner, T., Augustine, G.J., Feng, G., Euler, T. J. Neurosci. (2005) [Pubmed]
  13. Synthesis and opioid activity of [D-Pro10]dynorphin A-(1-11) analogues with N-terminal alkyl substitution. Choi, H., Murray, T.F., DeLander, G.E., Schmidt, W.K., Aldrich, J.V. J. Med. Chem. (1997) [Pubmed]
  14. Benzothiopyranoindazoles, a new class of chromophore modified anthracenedione anticancer agents. Synthesis and activity against murine leukemias. Showalter, H.D., Angelo, M.M., Berman, E.M., Kanter, G.D., Ortwine, D.F., Ross-Kesten, S.G., Sercel, A.D., Turner, W.R., Werbel, L.M., Worth, D.F. J. Med. Chem. (1988) [Pubmed]
  15. Biopharmaceutics of boronated radiosensitizers: liposomal formulation of MnBOPP (manganese chelate of 2,4-(alpha, beta-dihydroxyethyl) deuterioporphyrin IX) and comparative toxicity in mice. Zhou, R., Balasubramanian, S.V., Kahl, S.B., Straubinger, R.M. Journal of pharmaceutical sciences. (1999) [Pubmed]
  16. Carcinogenic risk assessment of MeIQx and PhIP in a newborn mouse two-stage tumorigenesis assay. Miyauchi, M., Nishikawa, A., Furukawa, F., Kasahara, K., Nakamura, H., Takahashi, M., Hirose, M. Cancer Lett. (1999) [Pubmed]
  17. Making the gradient: Thyroid hormone regulates cone opsin expression in the developing mouse retina. Roberts, M.R., Srinivas, M., Forrest, D., Morreale de Escobar, G., Reh, T.A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  18. Photoreceptors of Nrl -/- mice coexpress functional S- and M-cone opsins having distinct inactivation mechanisms. Nikonov, S.S., Daniele, L.L., Zhu, X., Craft, C.M., Swaroop, A., Pugh, E.N. J. Gen. Physiol. (2005) [Pubmed]
  19. Physiological function of S-cone system is not enhanced in rd7 mice. Ueno, S., Kondo, M., Miyata, K., Hirai, T., Miyata, T., Usukura, J., Nishizawa, Y., Miyake, Y. Exp. Eye Res. (2005) [Pubmed]
  20. Localization of protein kinase C to UV-sensitive photoreceptors in the mouse retina. Wikler, K.C., Stull, D.L., Reese, B.E., Johnson, P.T., Bogenmann, E. Vis. Neurosci. (1998) [Pubmed]
  21. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. Corbo, J.C., Cepko, C.L. PLoS Genet. (2005) [Pubmed]
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