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Gene Review:

TFPI - tissue factor pathway inhibitor...

Macaca mulatta

Synonyms: EPI, LACI

Tobu, M. et al., Kamei, S. et al., Hoppensteadt, D.A. et al.

Hoppensteadt, Fareed, Raake, Raake,

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High impact information on TFPI

Hence, gammaparin and heparin have similar TFPI release potential despite their differences in molecular weight [1].
Following the administration of 1 mg/kg of heparin, gammaparin, and C3, the functional levels of TFPI at 5 minutes were 2.40, 2.56, and 1.08 U/mL and the corresponding TFPI immunologic levels were 4.3-, 4.0-, and 2.1-fold, increased, respectively, over the baseline value [1].
Amino acid sequence and inhibitory activity of rhesus monkey tissue factor pathway inhibitor (TFPI): comparison with human TFPI [2].
Rhesus monkey cDNA for tissue factor pathway inhibitor (TFPI) was cloned by means of the reverse transcriptase-polymerase chain reaction, using liver mRNA, and its nucleotide sequence was determined by sequencing five independent clones [2].

Associations of TFPI with chemical compounds

From these results, it can be concluded that heparin and gammaparin produced similar levels of TFPI release [1].

Analytical, diagnostic and therapeutic context of TFPI

However, both the total and free TFPI levels were significantly and progressively elevated over the 10-day period in comparison to the placebo control group (P<.05) [3].

References

Comparative tissue factor pathway inhibitor release potential of heparins. Tobu, M., Ma, Q., Iqbal, O., Schultz, C., Jeske, W., Hoppensteadt, D.A., Fareed, J. Clin. Appl. Thromb. Hemost. (2005) [Pubmed]
Amino acid sequence and inhibitory activity of rhesus monkey tissue factor pathway inhibitor (TFPI): comparison with human TFPI. Kamei, S., Kamikubo, Y., Hamuro, T., Fujimoto, H., Ishihara, M., Yonemura, H., Miyamoto, S., Funatsu, A., Enjyoji, K., Abumiya, T. J. Biochem. (1994) [Pubmed]
Endogenous release of tissue factor pathway inhibitor by topical application of an ointment containing mucopolysaccharide polysulfate to nonhuman primates. Hoppensteadt, D.A., Fareed, J., Raake, P., Raake, W. Thromb. Res. (2001) [Pubmed]

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TFPI	Bos taurus
tfpia	Danio rerio
TFPI	Gallus gallus
TFPI	Homo sapiens
Tfpi	Mus musculus
TFPI	Pan troglodytes
Tfpi	Rattus norvegicus

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