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Gene Review

Tfpi  -  tissue factor pathway inhibitor...

Rattus norvegicus

Synonyms: EPI, Extrinsic pathway inhibitor, LACI, Lipoprotein-associated coagulation inhibitor, TFPI, ...
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Disease relevance of Tfpi


High impact information on Tfpi


Chemical compound and disease context of Tfpi

  • The imbalance between TF and TFPI seems to be important in promoting fibrin thrombus formation in the lung of endotoxin induced DIC condition [9].

Biological context of Tfpi


Anatomical context of Tfpi


Associations of Tfpi with chemical compounds


Regulatory relationships of Tfpi

  • TFPI is a multivalent Kunitz-type protease inhibitor that inhibits factor Xa via its second Kunitz domain and the factor VIIa/tissue factor (TF) complex via its first Kunitz domain [19].

Other interactions of Tfpi


Analytical, diagnostic and therapeutic context of Tfpi


  1. Intratracheal gene transfer of tissue factor pathway inhibitor attenuates pulmonary fibrosis. Kijiyama, N., Ueno, H., Sugimoto, I., Sasaguri, Y., Yatera, K., Kido, M., Gabazza, E.C., Suzuki, K., Hashimoto, E., Takeya, H. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  2. Effects of recombinant human tissue factor pathway inhibitor on thrombus formation and its in vivo distribution in a rat DIC model. Elsayed, Y.A., Nakagawa, K., Kamikubo, Y.I., Enjyoji, K.I., Kato, H., Sueishi, K. Am. J. Clin. Pathol. (1996) [Pubmed]
  3. Expression of tissue factor and tissue factor pathway inhibitor in rats lungs with lipopolysaccharide-induced disseminated intravascular coagulation. Hara, S., Asada, Y., Hatakeyama, K., Marutsuka, K., Sato, Y., Kisanuki, A., Sumiyoshi, A. Lab. Invest. (1997) [Pubmed]
  4. Production of tissue factor pathway inhibitor in cardiomyocytes and its upregulation by interleukin-1. Kereveur, A., Enjyoji, K., Masuda, K., Yutani, C., Kato, H. Thromb. Haemost. (2001) [Pubmed]
  5. The carboxy terminus of tissue factor pathway inhibitor is required for interacting with hepatoma cells in vitro and in vivo. Warshawsky, I., Bu, G., Mast, A., Saffitz, J.E., Broze, G.J., Schwartz, A.L. J. Clin. Invest. (1995) [Pubmed]
  6. Hypotension and inflammatory cytokine gene expression triggered by factor Xa-nitric oxide signaling. Papapetropoulos, A., Piccardoni, P., Cirino, G., Bucci, M., Sorrentino, R., Cicala, C., Johnson, K., Zachariou, V., Sessa, W.C., Altieri, D.C. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  7. The low density lipoprotein receptor-related protein mediates the cellular degradation of tissue factor pathway inhibitor. Warshawsky, I., Broze, G.J., Schwartz, A.L. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  8. Deranged blood coagulation equilibrium as a factor of massive liver necrosis following endotoxin administration in partially hepatectomized rats. Mochida, S., Arai, M., Ohno, A., Yamanobe, F., Ishikawa, K., Matsui, A., Maruyama, I., Kato, H., Fujiwara, K. Hepatology (1999) [Pubmed]
  9. The role of tissue factor in the pathogenesis of thrombosis and atherosclerosis. Asada, Y., Marutsuka, K., Hatakeyama, K., Sato, Y., Hara, S., Kisanuki, A., Sumiyoshi, A. J. Atheroscler. Thromb. (1998) [Pubmed]
  10. The expression of tissue factor and tissue factor pathway inhibitor in aortic smooth muscle cells is up-regulated in synthetic compared to contractile phenotype. Ghrib, F., Brisset, A.C., Dupouy, D., Terrisse, A.D., Navarro, C., Cadroy, Y., Boneu, B., Sié, P. Thromb. Haemost. (2002) [Pubmed]
  11. Thrombomodulin and tissue factor pathway inhibitor in endocardium of rapidly paced rat atria. Yamashita, T., Sekiguchi, A., Iwasaki, Y.K., Sagara, K., Hatano, S., Iinuma, H., Aizawa, T., Fu, L.T. Circulation (2003) [Pubmed]
  12. cDNA cloning and expression of rat tissue factor pathway inhibitor (TFPI). Enjyoji, K., Emi, M., Mukai, T., Kato, H. J. Biochem. (1992) [Pubmed]
  13. Regulation of inflammatory responses by natural anticoagulants. Okajima, K. Immunol. Rev. (2001) [Pubmed]
  14. The effects of angiotensin metabolites on the regulation of coagulation and fibrinolysis in cultured rat aortic endothelial cells. Nishimura, H., Tsuji, H., Masuda, H., Kasahara, T., Yoshizumi, M., Sugano, T., Kimura, S., Kawano, H., Kunieda, Y., Yano, S., Nakagawa, K., Kitamura, H., Nakahara, Y., Sawada, S., Nakagawa, M. Thromb. Haemost. (1999) [Pubmed]
  15. Angiotensin II increases plasminogen activator inhibitor-1 and tissue factor mRNA expression without changing that of tissue type plasminogen activator or tissue factor pathway inhibitor in cultured rat aortic endothelial cells. Nishimura, H., Tsuji, H., Masuda, H., Nakagawa, K., Nakahara, Y., Kitamura, H., Kasahara, T., Sugano, T., Yoshizumi, M., Sawada, S., Nakagawa, M. Thromb. Haemost. (1997) [Pubmed]
  16. Co-ordinate and restricted expression of the ProXaaArg/Lys-specific GalNAc-transferase and the GalNAc beta 1,4GlcNAc beta 1,2Man alpha-4-sulfotransferase. Dharmesh, S.M., Skelton, T.P., Baenziger, J.U. J. Biol. Chem. (1993) [Pubmed]
  17. Experimental haemorrhagic effect of two-domain non-glycosylated tissue factor pathway inhibitor compared to low molecular weight heparin. Holst, J., Lindblad, B., Matthíasson, S.E., Stjernquist, U., Ezban, M., Ostergaard, P.B., Hedner, U. Thromb. Haemost. (1996) [Pubmed]
  18. Does hypertension confer a hypercoagulable state in stroke-prone spontaneously hypertensive rats? Abumiya, T., Sakata, T., Enjyoji, K., Kato, H., Kawai, J., Suzuki, T., Masuda, J., Sasaguri, T., Ogata, J. J. Hypertens. (2000) [Pubmed]
  19. Structural requirements for TFPI-mediated inhibition of neointimal thickening after balloon injury in the rat. Han, X., Girard, T.J., Baum, P., Abendschein, D.R., Broze, G.J. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  20. Human ryudocan from endothelium-like cells binds basic fibroblast growth factor, midkine, and tissue factor pathway inhibitor. Kojima, T., Katsumi, A., Yamazaki, T., Muramatsu, T., Nagasaka, T., Ohsumi, K., Saito, H. J. Biol. Chem. (1996) [Pubmed]
  21. The effect of tissue factor pathway inhibitor on hepatic ischemic reperfusion injury of the rat. Yoshimura, N., Kobayashi, Y., Nakamura, K., Yamagishi, H., Oka, T. Transplantation (1999) [Pubmed]
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