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Gene Review

FEN1  -  flap structure-specific endonuclease 1

Bos taurus

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High impact information on FEN1

  • The initiator RNAs of mammalian Okazaki fragments are thought to be removed by RNase HI and the 5'-3' flap endonuclease (FEN1) [1].
  • Thus, a 5'-monoribonucleotide, particularly one that is made resistant to FEN-1/RTH-1-directed cleavage by extension of an inhibitory upstream primer, can be ligated into the chromosome, despite the presence of FEN-1/RTH-1 nuclease [2].


  1. Junction ribonuclease: an activity in Okazaki fragment processing. Murante, R.S., Henricksen, L.A., Bambara, R.A. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. Creation and removal of embedded ribonucleotides in chromosomal DNA during mammalian Okazaki fragment processing. Rumbaugh, J.A., Murante, R.S., Shi, S., Bambara, R.A. J. Biol. Chem. (1997) [Pubmed]
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