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Gene Review

Fen1  -  flap structure specific endonuclease 1

Mus musculus

Synonyms: AW538437, FEN-1, Fen-1, Flap endonuclease 1, Flap structure-specific endonuclease 1
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Disease relevance of Fen1


High impact information on Fen1


Biological context of Fen1


Anatomical context of Fen1


Associations of Fen1 with chemical compounds

  • Divalent metal ions, Mg(2+) or Mn(2+), are required for the active center of FEN-1 nucleases [7].

Regulatory relationships of Fen1

  • Fen1 is induced p53 dependently and involved in the recovery from UV-light-induced replication inhibition [5].

Other interactions of Fen1


Analytical, diagnostic and therapeutic context of Fen1

  • To assess the in vivo role of the mammalian enzyme in repair and replication, we used a gene-targeting approach to generate mice lacking a functional Fen1 gene [3].


  1. Disruption of the FEN-1/PCNA Interaction Results in DNA Replication Defects, Pulmonary Hypoplasia, Pancytopenia, and Newborn Lethality in Mice. Zheng, L., Dai, H., Qiu, J., Huang, Q., Shen, B. Mol. Cell. Biol. (2007) [Pubmed]
  2. Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression. Kucherlapati, M., Yang, K., Kuraguchi, M., Zhao, J., Lia, M., Heyer, J., Kane, M.F., Fan, K., Russell, R., Brown, A.M., Kneitz, B., Edelmann, W., Kolodner, R.D., Lipkin, M., Kucherlapati, R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stage. Larsen, E., Gran, C., Saether, B.E., Seeberg, E., Klungland, A. Mol. Cell. Biol. (2003) [Pubmed]
  4. Structure and transcription promoter activity of mouse flap endonuclease 1 gene: alternative splicing and bidirectional promoter. Emoto, M., Miki, M., Sarker, A.H., Nakamura, T., Seki, Y., Seki, S., Ikeda, S. Gene (2005) [Pubmed]
  5. Fen1 is induced p53 dependently and involved in the recovery from UV-light-induced replication inhibition. Christmann, M., Tomicic, M.T., Origer, J., Kaina, B. Oncogene (2005) [Pubmed]
  6. Sequence of human FEN-1, a structure-specific endonuclease, and chromosomal localization of the gene (FEN1) in mouse and human. Hiraoka, L.R., Harrington, J.J., Gerhard, D.S., Lieber, M.R., Hsieh, C.L. Genomics (1995) [Pubmed]
  7. Distinct roles of two Mg2+ binding sites in regulation of murine flap endonuclease-1 activities. Zheng, L., Li, M., Shan, J., Krishnamoorthi, R., Shen, B. Biochemistry (2002) [Pubmed]
  8. Mouse testicular extracts process DNA double-strand breaks efficiently by DNA end-to-end joining. Sathees, C.R., Raman, M.J. Mutat. Res. (1999) [Pubmed]
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