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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

rad2  -  FEN-1 endonuclease Rad2

Schizosaccharomyces pombe 972h-

 
 
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High impact information on rad2

  • To identify novel genes involved in DNA double-strand break (DSB) repair, we previously isolated Schizosaccharomyces pombe mutants which are hypersensitive to methyl methanesulfonate (MMS) and synthetic lethals with rad2 [1].
  • Thus, the function of Rad2 in mutation avoidance is rather independent of NER. rad13, swi10 and rad2, but not uve1 mutants were sensitive to the DNA-damaging agent methyl methane sulphonate [2].
  • However, the mutation spectra of rad2 were different from that of swi10 and rad13 [2].
  • In addition, S. pombe mutant for the flap endonuclease rad2 gene, whose precise function in DNA repair is unclear, were also more alkylation sensitive than mag1 mutants [3].
  • Gene conversion in nonsense suppressors of Schizosaccharomyces pombe. I. The influence of the genetic background and of three mutant genes (rad2, mut1 and mut2) on the frequency of the post-meiotic segregation [4].
 

Biological context of rad2

 

Other interactions of rad2

  • Rates were also elevated in the DNA nuclease-deficient strains rad2 (defective in the FEN-1 homologue) and exo1 [6].

References

  1. The Schizosaccharomyces pombe rad60 gene is essential for repairing double-strand DNA breaks spontaneously occurring during replication and induced by DNA-damaging agents. Morishita, T., Tsutsui, Y., Iwasaki, H., Shinagawa, H. Mol. Cell. Biol. (2002) [Pubmed]
  2. Role of the DNA repair nucleases Rad13, Rad2 and Uve1 of Schizosaccharomyces pombe in mismatch correction. Kunz, C., Fleck, O. J. Mol. Biol. (2001) [Pubmed]
  3. Contribution of base excision repair, nucleotide excision repair, and DNA recombination to alkylation resistance of the fission yeast Schizosaccharomyces pombe. Memisoglu, A., Samson, L. J. Bacteriol. (2000) [Pubmed]
  4. Gene conversion in nonsense suppressors of Schizosaccharomyces pombe. I. The influence of the genetic background and of three mutant genes (rad2, mut1 and mut2) on the frequency of the post-meiotic segregation. Munz, P., Leupold, U. Mol. Gen. Genet. (1979) [Pubmed]
  5. Genetic and physical interactions between Schizosaccharomyces pombe Mcl1 and Rad2, Dna2 and DNA polymerase alpha: evidence for a multifunctional role of Mcl1 in DNA replication and repair. Tsutsui, Y., Morishita, T., Natsume, T., Yamashita, K., Iwasaki, H., Yamao, F., Shinagawa, H. Curr. Genet. (2005) [Pubmed]
  6. Different frameshift mutation spectra in non-repetitive DNA of MutSalpha- and MutLalpha-deficient fission yeast cells. Marti, T.M., Mansour, A.A., Lehmann, E., Fleck, O. DNA Repair (Amst.) (2003) [Pubmed]
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