Gene Review:
FEN1 - flap structure-specific endonuclease 1
Homo sapiens
Synonyms:
DNase IV, FEN-1, Flap endonuclease 1, Flap structure-specific endonuclease 1, MF1, ...
- The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21. Gary, R., Ludwig, D.L., Cornelius, H.L., MacInnes, M.A., Park, M.S. J. Biol. Chem. (1997)
- Increased expression and no mutation of the Flap endonuclease (FEN1) gene in human lung cancer. Sato, M., Girard, L., Sekine, I., Sunaga, N., Ramirez, R.D., Kamibayashi, C., Minna, J.D. Oncogene (2003)
- Stimulation of human flap endonuclease 1 by human immunodeficiency virus type 1 integrase: possible role for flap endonuclease 1 in 5'-end processing of human immunodeficiency virus type 1 integration intermediates. Faust, E.A., Triller, H. J. Biomed. Sci. (2002)
- Distant structural homology leads to the functional characterization of an archaeal PIN domain as an exonuclease. Arcus, V.L., Bäckbro, K., Roos, A., Daniel, E.L., Baker, E.N. J. Biol. Chem. (2004)
- Nuclease-deficient FEN-1 blocks Rad51/BRCA1-mediated repair and causes trinucleotide repeat instability. Spiro, C., McMurray, C.T. Mol. Cell. Biol. (2003)
- Flap endonuclease 1: a central component of DNA metabolism. Liu, Y., Kao, H.I., Bambara, R.A. Annu. Rev. Biochem. (2004)
- Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity. Hosfield, D.J., Mol, C.D., Shen, B., Tainer, J.A. Cell (1998)
- Detection and purification of a novel 72 kDa glycoprotein male breast tumor associated antigen. Basu, A., Basu, I., Chakraborty, A., Pal, S., Chattopadhyay, U. Int. J. Cancer (2003)
- Differential recognition of microfilarial chitinase, a transmission-blocking vaccine candidate antigen, by sera from patients with Brugian and Bancroftian filariasis. Dissanayake, S., Perler, F.B., Xu, M., Southworth, M.W., Yee, C.K., Wang, S., Dreyer, G., Watawana, L., Kurniawan, L., Fuhrman, J.A. Am. J. Trop. Med. Hyg. (1995)
- Formaldehyde-limited cultivation of a newly isolated methylotrophic bacterium, Methylobacterium sp. MF1: enzymatic analysis related to C1 metabolism. Mitsui, R., Omori, M., Kitazawa, H., Tanaka, M. J. Biosci. Bioeng. (2005)
- Diagnosis, pathogenesis and treatment of the myeloproliferative disorders essential thrombocythemia, polycythemia vera and essential megakaryocytic granulocytic metaplasia and myelofibrosis. Michiels, J.J., Kutti, J., Stark, P., Bazzan, M., Gugliotta, L., Marchioli, R., Griesshammer, M., van Genderen, P.J., Brière, J., Kiladjian, J.J., Barbui, T., Finazzi, G., Berlin, N.I., Pearson, T.C., Green, A.C., Fruchtmann, S.M., Silver, R.T., Hansmann, E., Wehmeier, A., Lengfelder, E., Landolfi, R., Kvasnicka, H.M., Hasselbalch, H., Cervantes, F., Thiele, J. The Netherlands journal of medicine. (1999)
- Structural basis for recruitment of human flap endonuclease 1 to PCNA. Sakurai, S., Kitano, K., Yamaguchi, H., Hamada, K., Okada, K., Fukuda, K., Uchida, M., Ohtsuka, E., Morioka, H., Hakoshima, T. EMBO J. (2005)
- The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1. Wang, W., Brandt, P., Rossi, M.L., Lindsey-Boltz, L., Podust, V., Fanning, E., Sancar, A., Bambara, R.A. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Single nucleotide polymorphism analyses of the human proliferating cell nuclear antigen (pCNA) and flap endonuclease (FEN1) genes. Ma, X., Jin, Q., Försti, A., Hemminki, K., Kumar, R. Int. J. Cancer (2000)
- Two overlapping divergent transcription units in the human genome: the FEN1/C11orf10 locus. Adachi, N., Karanjawala, Z.E., Matsuzaki, Y., Koyama, H., Lieber, M.R. OMICS (2002)
- Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity. Brosh, R.M., von Kobbe, C., Sommers, J.A., Karmakar, P., Opresko, P.L., Piotrowski, J., Dianova, I., Dianov, G.L., Bohr, V.A. EMBO J. (2001)
- FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair. Prasad, R., Dianov, G.L., Bohr, V.A., Wilson, S.H. J. Biol. Chem. (2000)
- Fen1 expression: a novel marker for cell proliferation. Warbrick, E., Coates, P.J., Hall, P.A. J. Pathol. (1998)
- AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair. Ranalli, T.A., Tom, S., Bambara, R.A. J. Biol. Chem. (2002)
- High mobility of flap endonuclease 1 and DNA polymerase eta associated with replication foci in mammalian S-phase nucleus. Solovjeva, L., Svetlova, M., Sasina, L., Tanaka, K., Saijo, M., Nazarov, I., Bradbury, M., Tomilin, N. Mol. Biol. Cell (2005)
- The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities. Lee, B.I., Wilson, D.M. J. Biol. Chem. (1999)
- Defective flap endonuclease 1 activity in mammalian cells is associated with impaired DNA repair and prolonged S phase delay. Shibata, Y., Nakamura, T. J. Biol. Chem. (2002)
- Concerted Action of Exonuclease and Gap-dependent Endonuclease Activities of FEN-1 Contributes to the Resolution of Triplet Repeat Sequences (CTG)n- and (GAA)n-derived Secondary Structures Formed during Maturation of Okazaki Fragments. Singh, P., Zheng, L., Chavez, V., Qiu, J., Shen, B. J. Biol. Chem. (2007)
- Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases. Shen, B., Singh, P., Liu, R., Qiu, J., Zheng, L., Finger, L.D., Alas, S. Bioessays (2005)
- Gene expression of flap endonuclease-1 during cell proliferation and differentiation. Kim, I.S., Lee, M.Y., Lee, I.H., Shin, S.L., Lee, S.Y. Biochim. Biophys. Acta (2000)
- The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA. Sharma, S., Sommers, J.A., Gary, R.K., Friedrich-Heineken, E., Hübscher, U., Brosh, R.M. Nucleic Acids Res. (2005)
- Mechanisms by which bloom protein can disrupt recombination intermediates of okazaki fragment maturation. Bartos, J.D., Wang, W., Pike, J.E., Bambara, R.A. J. Biol. Chem. (2006)
- p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex. Chen, U., Chen, S., Saha, P., Dutta, A. Proc. Natl. Acad. Sci. U.S.A. (1996)
- The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein. Sharma, S., Sommers, J.A., Driscoll, H.C., Uzdilla, L., Wilson, T.M., Brosh, R.M. J. Biol. Chem. (2003)
- Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation. Henneke, G., Koundrioukoff, S., Hübscher, U. Oncogene (2003)
- Early immobilization of nuclease FEN1 and accumulation of hRAD18 protein at stalled DNA replication forks in mammalian cells. Nikiforov, A.A., Sasina, L.K., Svetlova, M.P., Solovjeva, L.V., Oei, S.L., Bradbury, E.M., Tomilin, N.V. Dokl. Biochem. Biophys. (2003)
- Preparation and crystallization of human flap endonuclease FEN-1 in complex with proliferating-cell nuclear antigen, PCNA. Sakurai, S., Kitano, K., Okada, K., Hamada, K., Morioka, H., Hakoshima, T. Acta Crystallogr. D Biol. Crystallogr. (2003)
- Flap endonuclease disengages dna2 helicase/nuclease from okazaki fragment flaps. Stewart, J.A., Campbell, J.L., Bambara, R.A. J. Biol. Chem. (2006)