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Gene Review

FKBPL  -  FK506 binding protein like

Homo sapiens

Synonyms: DIR1, FK506-binding protein-like, NG7, WAF-1/CIP1 stabilizing protein 39, WISP39, ...
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Disease relevance of FKBPL

  • MATERIALS AND METHODS: Three cell lines, V79, RT112 and UM-UC-3, which are known to exhibit low-dose hypersensitivity (HRS) and induced radioresistance (IRR), and the radiosensitive cell line ATBIVA, were transfected with antisense oligonucleotides directed towards the DIR1 gene [1].
  • The utility of the assay has been demonstrated by the determination of the Michaelis-Menten constants of cytosolic cyclophilin (Cyp18) and of the proteolytically sensitive FK506-binding protein-like PPIase SlyD from Escherichia coli [2].

High impact information on FKBPL

  • Increased repair and cell survival in cells treated with DIR1 antisense oligonucleotides: implications for induced radioresistance [1].
  • RESULTS: Following treatment with 4Gy X-rays, the V79, RT112 and UM-UC-3 cell lines all exhibited significantly increased rates of ssb repair after transfection with DIR1 antisense oligonucleotides compared with cells transfected with scrambled oligonucleotides [1].
  • Antisense strategies have demonstrated that the DIR1 gene also appears to have some involvement in the control of the cell cycle [3].
  • There was no significant difference between the affected and unaffected subjects in the allele frequency of Dir1 [4].
  • The polymorphism of a long and unstable CAG/CTG trinucleotide repeat, Dir1, was studied by PCR [4].

Anatomical context of FKBPL

  • CONCLUSIONS: Repression of the DIR1 gene product leads to an increase in the rate of repair and cell survival in three radioresistant cells lines but not in the radiosensitive ATBIVA cell line [1].


  1. Increased repair and cell survival in cells treated with DIR1 antisense oligonucleotides: implications for induced radioresistance. Robson, T., Price, M.E., Moore, M.L., Joiner, M.C., McKelvey-Martin, V.J., McKeown, S.R., Hirst, D.G. Int. J. Radiat. Biol. (2000) [Pubmed]
  2. A protease-free assay for peptidyl prolyl cis/trans isomerases using standard peptide substrates. Janowski, B., Wöllner, S., Schutkowski, M., Fischer, G. Anal. Biochem. (1997) [Pubmed]
  3. A novel human stress response-related gene with a potential role in induced radioresistance. Robson, T., Joiner, M.C., Wilson, G.D., McCullough, W., Price, M.E., Logan, I., Jones, H., McKeown, S.R., Hirst, D.G. Radiat. Res. (1999) [Pubmed]
  4. A CAG trinucleotide repeat expansion and familial schizophrenia. Ohara1, K., Ikeuchi, T., Suzuki, Y., Ohtani, M., Ohara, K., Tsuji, S. Psychiatry research. (2000) [Pubmed]
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