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Gene Review:

SEC13 - SEC13 homolog (S. cerevisiae)

Homo sapiens

Synonyms: D3S1231E, Protein SEC13 homolog, SEC13-like protein 1, SEC13-related protein, SEC13L1, ...

Swaroop, A. et al., Shaywitz, D.A. et al.

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Disease relevance of SEC13

SEC13R was physically mapped to a yeast artificial chromosome (YAC) clone spanning the D3S720 marker from the region of the Von Hippel-Lindau disease locus [1].

High impact information on SEC13

Human SEC13Rp functions in yeast and is located on transport vesicles budding from the endoplasmic reticulum [2].
We also show that the distribution of SEC13Rp is not affected by brefeldin A treatment [2].
Somatic cell hybrid and in situ hybridization studies localized the SEC13R gene to human chromosome 3p24-p25 [1].
Molecular characterization of a novel human gene, SEC13R, related to the yeast secretory pathway gene SEC13, and mapping to a conserved linkage group on human chromosome 3p24-p25 and mouse chromosome 6 [1].
The nucleotide sequence of one of the cDNA clones, AA35 (D3S1231E), showed strong homology to the yeast SEC13 gene, required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins [1].

References

Molecular characterization of a novel human gene, SEC13R, related to the yeast secretory pathway gene SEC13, and mapping to a conserved linkage group on human chromosome 3p24-p25 and mouse chromosome 6. Swaroop, A., Yang-Feng, T.L., Liu, W., Gieser, L., Barrow, L.L., Chen, K.C., Agarwal, N., Meisler, M.H., Smith, D.I. Hum. Mol. Genet. (1994) [Pubmed]
Human SEC13Rp functions in yeast and is located on transport vesicles budding from the endoplasmic reticulum. Shaywitz, D.A., Orci, L., Ravazzola, M., Swaroop, A., Kaiser, C.A. J. Cell Biol. (1995) [Pubmed]

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AgaP_AGAP003183	Anopheles gambiae str. PEST
AT3G01340	Arabidopsis thaliana
AT2G30050	Arabidopsis thaliana
AGOS_ACR199C	Ashbya gossypii ATCC 10895
SEC13	Bos taurus
npp-20	Caenorhabditis elegans
SEC13	Canis lupus familiaris
sec13	Danio rerio
Sec13	Drosophila melanogaster
SEC13	Gallus gallus
KLLA0C16643g	Kluyveromyces lactis NRRL Y-1140
SEC13	Macaca mulatta
MGG_14666	Magnaporthe oryzae 70-15
Sec13	Mus musculus
NCU04063	Neurospora crassa OR74A
Os02g0135800	Oryza sativa Japonica Group
SEC13	Pan troglodytes
Sec13	Rattus norvegicus
SEC13	Saccharomyces cerevisiae S288c
sec13	Schizosaccharomyces pombe 972h-
sec13	Xenopus (Silurana) tropicalis

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