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Gene Review:

SLC28A3 - solute carrier family 28 (concentrative...

Homo sapiens

Synonyms: CNT 3, CNT3, Concentrative Na(+)-nucleoside cotransporter 3, Solute carrier family 28 member 3, hCNT3

Damaraju, S. et al., Badagnani, I. et al.

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High impact information on SLC28A3

The human concentrative nucleoside transporter, CNT3 (SLC28A3), plays an important role in mediating the cellular entry of a broad array of physiological nucleosides and synthetic anticancer nucleoside analog drugs [1].
Identification and functional characterization of variants in human concentrative nucleoside transporter 3, hCNT3 (SLC28A3), arising from single nucleotide polymorphisms in coding regions of the hCNT3 gene [2].
In all, 56 variable sites in the exons and flanking intronic region of SLC28A3 were identified in a collection of 270 DNA samples from US populations (80 African-Americans, 80 European-Americans, 60 Asian-Americans, and 50 Mexican-Americans) [1].

Associations of SLC28A3 with chemical compounds

INTRODUCTION: Human concentrative nucleoside transporter 3, hCNT3 (SLC28A3), which mediates transport of purine and pyrimidine nucleosides and a variety of antiviral and anticancer nucleoside drugs, was investigated to determine if there are single nucleotide polymorphisms in the coding regions of the hCNT3 gene [2].

References

Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3). Badagnani, I., Chan, W., Castro, R.A., Brett, C.M., Huang, C.C., Stryke, D., Kawamoto, M., Johns, S.J., Ferrin, T.E., Carlson, E.J., Burchard, E.G., Giacomini, K.M. Pharmacogenomics J. (2005) [Pubmed]
Identification and functional characterization of variants in human concentrative nucleoside transporter 3, hCNT3 (SLC28A3), arising from single nucleotide polymorphisms in coding regions of the hCNT3 gene. Damaraju, S., Zhang, J., Visser, F., Tackaberry, T., Dufour, J., Smith, K.M., Slugoski, M., Ritzel, M.W., Baldwin, S.A., Young, J.D., Cass, C.E. Pharmacogenet. Genomics (2005) [Pubmed]

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AgaP_AGAP005988	Anopheles gambiae str. PEST
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NCU08148	Neurospora crassa OR74A
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