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MeSH Review

Mexican Americans

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Disease relevance of Mexican Americans


Psychiatry related information on Mexican Americans


High impact information on Mexican Americans

  • A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2 [11].
  • The peak on chromosome 2 coincided with the region containing the gene (POMC) encoding pro-opiomelanocortin, a locus previously linked to leptin levels and fat mass in a Mexican-American population and shown to be mutated in obese humans [12].
  • We have screened the human genome for susceptibility genes for NIDDM using non-and quasi-parametric linkage analysis methods in a group of Mexican American affected sib pairs [2].
  • CONCLUSIONS: Estimates of prevalence of HFE mutations are within the expected range for non-Hispanic whites and blacks but the estimated prevalence of the C282Y mutation among Mexican-Americans is less than expected [13].
  • OBJECTIVE: To investigate differences in levels of serum cotinine in black, white, and Mexican American cigarette smokers in the US adult population [14].

Chemical compound and disease context of Mexican Americans


Biological context of Mexican Americans


Anatomical context of Mexican Americans


Associations of Mexican Americans with chemical compounds

  • In univariate analysis, factors associated with elevated ALT levels (P < 0.05) included younger age, male sex, Mexican-American ethnicity, and higher BMI, waist-to-hip circumference ratio (WHR), and fasting serum leptin, triglyceride, insulin, and glucose concentrations [29].
  • Immigration and lifetime prevalence of DSM-IV psychiatric disorders among Mexican Americans and non-Hispanic whites in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions [30].
  • Therefore, we conducted a genomewide scan for susceptibility genes influencing plasma triglyceride (TG) levels in a Mexican American population [31].
  • Serum bilirubin levels are significantly higher in men (0.72 +/- 0.004) than in women (0.52 +/- 0.003 mg/dL) and are lower in non-Hispanic blacks (0.55 +/- 0.005 mg/dL) compared with non-Hispanic whites (0.63 +/- 0.004 mg/dL) and Mexican Americans (0.61 +/- 0.005 mg/dL) [32].
  • Incidence rates were higher among the Hispanic, Mexican-American, Pima, and Nauruan populations than among Caucasians [33].

Gene context of Mexican Americans


Analytical, diagnostic and therapeutic context of Mexican Americans


  1. Hyperinsulinemia in a population at high risk for non-insulin-dependent diabetes mellitus. Haffner, S.M., Stern, M.P., Hazuda, H.P., Pugh, J.A., Patterson, J.K. N. Engl. J. Med. (1986) [Pubmed]
  2. A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Hanis, C.L., Boerwinkle, E., Chakraborty, R., Ellsworth, D.L., Concannon, P., Stirling, B., Morrison, V.A., Wapelhorst, B., Spielman, R.S., Gogolin-Ewens, K.J., Shepard, J.M., Williams, S.R., Risch, N., Hinds, D., Iwasaki, N., Ogata, M., Omori, Y., Petzold, C., Rietzch, H., Schröder, H.E., Schulze, J., Cox, N.J., Menzel, S., Boriraj, V.V., Chen, X., Lim, L.R., Lindner, T., Mereu, L.E., Wang, Y.Q., Xiang, K., Yamagata, K., Yang, Y., Bell, G.I. Nat. Genet. (1996) [Pubmed]
  3. Herpes simplex virus type 2 in the United States, 1976 to 1994. Fleming, D.T., McQuillan, G.M., Johnson, R.E., Nahmias, A.J., Aral, S.O., Lee, F.K., St Louis, M.E. N. Engl. J. Med. (1997) [Pubmed]
  4. HLA class II DR-DQ amino acids and insulin-dependent diabetes mellitus: application of the haplotype method. Valdes, A.M., McWeeney, S., Thomson, G. Am. J. Hum. Genet. (1997) [Pubmed]
  5. NIDDM is the major cause of diabetic end-stage renal disease. More evidence from a tri-ethnic community. Pugh, J.A., Medina, R.A., Cornell, J.C., Basu, S. Diabetes (1995) [Pubmed]
  6. Return rates and outcomes from ethnicity-specific mental health programs in Los Angeles. Takeuchi, D.T., Sue, S., Yeh, M. American journal of public health. (1995) [Pubmed]
  7. Ethnic differences in the psychosocial antecedents of needle/syringe disinfection. Longshore, D., Stein, J.A., Anglin, M.D. Drug and alcohol dependence. (1996) [Pubmed]
  8. DSM-IV alcohol dependence and drug abuse/dependence in a treatment sample of whites, blacks and Mexican Americans. Caetano, R., Schafer, J. Drug and alcohol dependence. (1996) [Pubmed]
  9. Prevalence of dementia in older latinos: the influence of type 2 diabetes mellitus, stroke and genetic factors. Haan, M.N., Mungas, D.M., Gonzalez, H.M., Ortiz, T.A., Acharya, A., Jagust, W.J. Journal of the American Geriatrics Society. (2003) [Pubmed]
  10. Initial validation of the Personality Assessment Inventory-Spanish version with clients from Mexican American communities. Rogers, R., Flores, J., Ustad, K., Sewell, K.W. Journal of personality assessment. (1995) [Pubmed]
  11. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Horikawa, Y., Oda, N., Cox, N.J., Li, X., Orho-Melander, M., Hara, M., Hinokio, Y., Lindner, T.H., Mashima, H., Schwarz, P.E., del Bosque-Plata, L., Horikawa, Y., Oda, Y., Yoshiuchi, I., Colilla, S., Polonsky, K.S., Wei, S., Concannon, P., Iwasaki, N., Schulze, J., Baier, L.J., Bogardus, C., Groop, L., Boerwinkle, E., Hanis, C.L., Bell, G.I. Nat. Genet. (2000) [Pubmed]
  12. A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10. Hager, J., Dina, C., Francke, S., Dubois, S., Houari, M., Vatin, V., Vaillant, E., Lorentz, N., Basdevant, A., Clement, K., Guy-Grand, B., Froguel, P. Nat. Genet. (1998) [Pubmed]
  13. Prevalence of C282Y and H63D mutations in the hemochromatosis (HFE) gene in the United States. Steinberg, K.K., Cogswell, M.E., Chang, J.C., Caudill, S.P., McQuillan, G.M., Bowman, B.A., Grummer-Strawn, L.M., Sampson, E.J., Khoury, M.J., Gallagher, M.L. JAMA (2001) [Pubmed]
  14. Racial and ethnic differences in serum cotinine levels of cigarette smokers: Third National Health and Nutrition Examination Survey, 1988-1991. Caraballo, R.S., Giovino, G.A., Pechacek, T.F., Mowery, P.D., Richter, P.A., Strauss, W.J., Sharp, D.J., Eriksen, M.P., Pirkle, J.L., Maurer, K.R. JAMA (1998) [Pubmed]
  15. Does obesity explain excess prevalence of diabetes among Mexican Americans? Results of the San Antonio Heart Study. Stern, M.P., Gaskill, S.P., Hazuda, H.P., Gardner, L.I., Haffner, S.M. Diabetologia (1983) [Pubmed]
  16. Metabolic precursors of hypertension. The San Antonio Heart Study. Haffner, S.M., Miettinen, H., Gaskill, S.P., Stern, M.P. Arch. Intern. Med. (1996) [Pubmed]
  17. Nutrition surveillance in Arizona: selected anthropometric and laboratory observations among Mexican-American children. Yanochik-Owen, A., White, M. American journal of public health. (1977) [Pubmed]
  18. Neural tube defects among Mexican Americans living on the US-Mexico border: effects of folic acid and dietary folate. Suarez, L., Hendricks, K.A., Cooper, S.P., Sweeney, A.M., Hardy, R.J., Larsen, R.D. Am. J. Epidemiol. (2000) [Pubmed]
  19. D2 dopamine receptor gene polymorphisms among African-Americans and Mexican-Americans: a lung cancer case-control study. Wu, X., Hudmon, K.S., Detry, M.A., Chamberlain, R.M., Spitz, M.R. Cancer Epidemiol. Biomarkers Prev. (2000) [Pubmed]
  20. Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians. Rasmussen, S.K., Urhammer, S.A., Berglund, L., Jensen, J.N., Hansen, L., Echwald, S.M., Borch-Johnsen, K., Horikawa, Y., Mashima, H., Lithell, H., Cox, N.J., Hansen, T., Bell, G.I., Pedersen, O. Diabetes (2002) [Pubmed]
  21. Lipoprotein lipase is a gene for insulin resistance in Mexican Americans. Goodarzi, M.O., Guo, X., Taylor, K.D., Quiñones, M.J., Saad, M.F., Yang, H., Hsueh, W.A., Rotter, J.I. Diabetes (2004) [Pubmed]
  22. HLA-DRB1 alleles associated with susceptibility or resistance to rheumatoid arthritis, articular deformities, and disability in Mexican Americans. del Rincón, I., Escalante, A. Arthritis Rheum. (1999) [Pubmed]
  23. Vitamin D receptor polymorphisms, bone mineral density, and bone metabolism in postmenopausal Mexican-American women. McClure, L., Eccleshall, T.R., Gross, C., Villa, M.L., Lin, N., Ramaswamy, V., Kohlmeier, L., Kelsey, J.L., Marcus, R., Feldman, D. J. Bone Miner. Res. (1997) [Pubmed]
  24. Linkage studies in NIDDM with markers near the sulphonylurea receptor gene. Stirling, B., Cox, N.J., Bell, G.I., Hanis, C.L., Spielman, R.S., Concannon, P. Diabetologia (1995) [Pubmed]
  25. A genomewide search finds major susceptibility loci for gallbladder disease on chromosome 1 in Mexican Americans. Puppala, S., Dodd, G.D., Fowler, S., Arya, R., Schneider, J., Farook, V.S., Granato, R., Dyer, T.D., Almasy, L., Jenkinson, C.P., Diehl, A.K., Stern, M.P., Blangero, J., Duggirala, R. Am. J. Hum. Genet. (2006) [Pubmed]
  26. Association of the diabetes gene calpain-10 with subclinical atherosclerosis: the Mexican-American Coronary Artery Disease Study. Goodarzi, M.O., Taylor, K.D., Guo, X., Quiñones, M.J., Cui, J., Li, Y., Saad, M.F., Yang, H., Hsueh, W.A., Hodis, H.N., Rotter, J.I. Diabetes (2005) [Pubmed]
  27. Serum and red blood cell folate concentrations, race, and education: findings from the third National Health and Nutrition Examination Survey. Ford, E.S., Bowman, B.A. Am. J. Clin. Nutr. (1999) [Pubmed]
  28. Hyperinsulinemia as a possible etiology for the high prevalence of non insulin dependent diabetes in Mexican Americans. Haffner, S.M. Diabète & métabolisme. (1987) [Pubmed]
  29. Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States. Ruhl, C.E., Everhart, J.E. Gastroenterology (2003) [Pubmed]
  30. Immigration and lifetime prevalence of DSM-IV psychiatric disorders among Mexican Americans and non-Hispanic whites in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Grant, B.F., Stinson, F.S., Hasin, D.S., Dawson, D.A., Chou, S.P., Anderson, K. Arch. Gen. Psychiatry (2004) [Pubmed]
  31. A major susceptibility locus influencing plasma triglyceride concentrations is located on chromosome 15q in Mexican Americans. Duggirala, R., Blangero, J., Almasy, L., Dyer, T.D., Williams, K.L., Leach, R.J., O'Connell, P., Stern, M.P. Am. J. Hum. Genet. (2000) [Pubmed]
  32. Serum bilirubin levels in the U.S. population: gender effect and inverse correlation with colorectal cancer. Zucker, S.D., Horn, P.S., Sherman, K.E. Hepatology (2004) [Pubmed]
  33. Predictors of progression from impaired glucose tolerance to NIDDM: an analysis of six prospective studies. Edelstein, S.L., Knowler, W.C., Bain, R.P., Andres, R., Barrett-Connor, E.L., Dowse, G.K., Haffner, S.M., Pettitt, D.J., Sorkin, J.D., Muller, D.C., Collins, V.R., Hamman, R.F. Diabetes (1997) [Pubmed]
  34. Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1). Sahoo, T., Johnson, E.W., Thomas, J.W., Kuehl, P.M., Jones, T.L., Dokken, C.G., Touchman, J.W., Gallione, C.J., Lee-Lin, S.Q., Kosofsky, B., Kurth, J.H., Louis, D.N., Mettler, G., Morrison, L., Gil-Nagel, A., Rich, S.S., Zabramski, J.M., Boguski, M.S., Green, E.D., Marchuk, D.A. Hum. Mol. Genet. (1999) [Pubmed]
  35. Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans. Licinio, J., O'Kirwan, F., Irizarry, K., Merriman, B., Thakur, S., Jepson, R., Lake, S., Tantisira, K.G., Weiss, S.T., Wong, M.L. Mol. Psychiatry (2004) [Pubmed]
  36. Association of the calpain-10 gene with type 2 diabetes mellitus in a Mexican population. del Bosque-Plata, L., Aguilar-Salinas, C.A., Tusié-Luna, M.T., Ramírez-Jiménez, S., Rodríguez-Torres, M., Aurón-Gómez, M., Ramírez, E., Velasco-Pérez, M.L., Ramírez-Silva, A., Gómez-Pérez, F., Hanis, C.L., Tsuchiya, T., Yoshiuchi, I., Cox, N.J., Bell, G.I. Mol. Genet. Metab. (2004) [Pubmed]
  37. Three new HLA-B alleles found in Mexican-Americans. Adams, E.J., Little, A.M., Arnett, K.L., McAuley, J.E., Williams, R.C., Parham, P. Tissue Antigens (1995) [Pubmed]
  38. Incidence of type II diabetes in Mexican Americans predicted by fasting insulin and glucose levels, obesity, and body-fat distribution. Haffner, S.M., Stern, M.P., Mitchell, B.D., Hazuda, H.P., Patterson, J.K. Diabetes (1990) [Pubmed]
  39. Proinsulin and specific insulin concentration in high- and low-risk populations for NIDDM. Haffner, S.M., Bowsher, R.R., Mykkänen, L., Hazuda, H.P., Mitchell, B.D., Valdez, R.A., Gingerich, R., Monterossa, A., Stern, M.P. Diabetes (1994) [Pubmed]
  40. Leptin concentrations in diabetic and nondiabetic Mexican-Americans. Haffner, S.M., Stern, M.P., Miettinen, H., Wei, M., Gingerich, R.L. Diabetes (1996) [Pubmed]
  41. Relationship between age and serum vitamin A in children aged 4-11 y. Lewis, C.J., McDowell, M.A., Sempos, C.T., Lewis, K.C., Yetley, E.A. Am. J. Clin. Nutr. (1990) [Pubmed]
  42. Racial and ethnic differences in glycemic control of adults with type 2 diabetes. Harris, M.I., Eastman, R.C., Cowie, C.C., Flegal, K.M., Eberhardt, M.S. Diabetes Care (1999) [Pubmed]
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