Gene Review:
SLC28A1 - solute carrier family 28 (concentrative...
Homo sapiens
Synonyms:
CNT 1, CNT1, Concentrative nucleoside transporter 1, HCNT1, Na(+)/nucleoside cotransporter 1, ...
- Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2',2'-difluorodeoxycytidine- induced cytotoxicity. García-Manteiga, J., Molina-Arcas, M., Casado, F.J., Mazo, A., Pastor-Anglada, M. Clin. Cancer Res. (2003)
- Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. Ritzel, M.W., Yao, S.Y., Ng, A.M., Mackey, J.R., Cass, C.E., Young, J.D. Mol. Membr. Biol. (1998)
- Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors. Farré, X., Guillén-Gómez, E., Sánchez, L., Hardisson, D., Plaza, Y., Lloberas, J., Casado, F.J., Palacios, J., Pastor-Anglada, M. Int. J. Cancer (2004)
- Gemcitabine transport in xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters. Mackey, J.R., Yao, S.Y., Smith, K.M., Karpinski, E., Baldwin, S.A., Cass, C.E., Young, J.D. J. Natl. Cancer Inst. (1999)
- Interaction of nucleoside inhibitors of HIV-1 reverse transcriptase with the concentrative nucleoside transporter-1 (SLC28A1). Cano-Soldado, P., Lorráyoz, I.M., Molina-Arcas, M., Casado, F.J., Martinez-Picado, J., Lostao, M.P., Pastor-Anglada, M. Antivir. Ther. (Lond.) (2004)
- Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells. Fern??ndez-Veledo, S., Jover, R., Casado, F.J., G??mez-Lech??n, M.J., Pastor-Anglada, M. Biochem. Biophys. Res. Commun. (2007)
- The concentrative nucleoside transporter family (SLC28): new roles beyond salvage? Aymerich, I., Duflot, S., Fernández-Veledo, S., Guillén-Gómez, E., Huber-Ruano, I., Casado, F.J., Pastor-Anglada, M. Biochem. Soc. Trans. (2005)
- The role of human nucleoside transporters in cellular uptake of 4'-thio-beta-D-arabinofuranosylcytosine and beta-D-arabinosylcytosine. Clarke, M.L., Damaraju, V.L., Zhang, J., Mowles, D., Tackaberry, T., Lang, T., Smith, K.M., Young, J.D., Tomkinson, B., Cass, C.E. Mol. Pharmacol. (2006)
- Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2. Loewen, S.K., Ng, A.M., Yao, S.Y., Cass, C.E., Baldwin, S.A., Young, J.D. J. Biol. Chem. (1999)
- The concentrative nucleoside transporter family, SLC28. Gray, J.H., Owen, R.P., Giacomini, K.M. Pflugers Arch. (2004)
- Conserved glutamate residues are critically involved in Na+/nucleoside cotransport by human concentrative nucleoside transporter 1 (hCNT1). Yao, S.Y., Ng, A.M., Slugoski, M.D., Smith, K.M., Mulinta, R., Karpinski, E., Cass, C.E., Baldwin, S.A., Young, J.D. J. Biol. Chem. (2007)
- A proton-mediated conformational shift identifies a mobile pore-lining cysteine residue (Cys-561) in human concentrative nucleoside transporter 3. Slugoski, M.D., Ng, A.M., Yao, S.Y., Smith, K.M., Lin, C.C., Zhang, J., Karpinski, E., Cass, C.E., Baldwin, S.A., Young, J.D. J. Biol. Chem. (2008)
- Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3). Badagnani, I., Chan, W., Castro, R.A., Brett, C.M., Huang, C.C., Stryke, D., Kawamoto, M., Johns, S.J., Ferrin, T.E., Carlson, E.J., Burchard, E.G., Giacomini, K.M. Pharmacogenomics J. (2005)
- Simultaneous expression of hCNT1-CFP and hENT1-YFP in Madin-Darby canine kidney cells. Localization and vectorial transport studies. Lai, Y., Bakken, A.H., Unadkat, J.D. J. Biol. Chem. (2002)
- TGF-beta transcriptionally activates the gene encoding the high-affinity adenosine transporter CNT2 in rat liver parenchymal cells. Vald??s, R., Fern??ndez-Veledo, S., Aymerich, I., Casado, F.J., Pastor-Anglada, M. Cell. Mol. Life Sci. (2006)
- Expression of the high-affinity fluoropyrimidine-preferring nucleoside transporter hCNT1 correlates with decreased disease-free survival in breast cancer. Gloeckner-Hofmann, K., Guillén-Gómez, E., Schmidtgen, C., Porstmann, R., Ziegler, R., Stoss, O., Casado, F.J., Rüschoff, J., Pastor-Anglada, M. Oncology (2006)
- The broadly selective human Na+/nucleoside cotransporter (hCNT3) exhibits novel cation-coupled nucleoside transport characteristics. Smith, K.M., Slugoski, M.D., Loewen, S.K., Ng, A.M., Yao, S.Y., Chen, X.Z., Karpinski, E., Cass, C.E., Baldwin, S.A., Young, J.D. J. Biol. Chem. (2005)
- The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma. Spratlin, J., Sangha, R., Glubrecht, D., Dabbagh, L., Young, J.D., Dumontet, C., Cass, C., Lai, R., Mackey, J.R. Clin. Cancer Res. (2004)
- Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1). Ritzel, M.W., Yao, S.Y., Huang, M.Y., Elliott, J.F., Cass, C.E., Young, J.D. Am. J. Physiol. (1997)
- The increment of purine specific sodium nucleoside cotransporter mRNA in experimental fibrotic liver induced by bile duct ligation and scission. Lee, S.H., Chae, K.S., Nan, J.X., Sohn, D.H. Arch. Pharm. Res. (2000)
- Uridine binding motifs of human concentrative nucleoside transporters 1 and 3 produced in Saccharomyces cerevisiae. Zhang, J., Visser, F., Vickers, M.F., Lang, T., Robins, M.J., Nielsen, L.P., Nowak, I., Baldwin, S.A., Young, J.D., Cass, C.E. Mol. Pharmacol. (2003)