Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

KC6 - keratoconus gene 6

Homo sapiens

Rabinowitz, Y.S. et al., Calhoun, K.A. et al.

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Disease relevance of KC6

Next, we created Escherichia coli strain KC6 that combines a gshA deletion with previously described deletions for arginine, serine, and tryptophan stabilization [1].

High impact information on KC6

KC6 is a novel gene of unknown function that shows cornea-preferred expression, whereas the suppression of transcripts for AQP5 provides the first clear evidence of a molecular defect identified in KC [2].
One cluster of six clones came from an apparently novel gene (designated KC6) located on chromosome 18 at p12 [2].

Analytical, diagnostic and therapeutic context of KC6

3. RT-PCR of RNA from several human tissues detected KC6 transcripts only in cornea [2].

References

Total amino acid stabilization during cell-free protein synthesis reactions. Calhoun, K.A., Swartz, J.R. J. Biotechnol. (2006) [Pubmed]
Gene expression profile studies of human keratoconus cornea for NEIBank: a novel cornea-expressed gene and the absence of transcripts for aquaporin 5. Rabinowitz, Y.S., Dong, L., Wistow, G. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]

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