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Gene Review

MOP-1  -  MOP-1

Homo sapiens

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High impact information on MOP-1

  • The observation that mop1 affects paramutation at multiple loci, despite major differences between these loci in their gene structure, correlations with DNA methylation, and stability of the paramutant state, suggests that a common mechanism underlies paramutation [1].
  • In mop1 mutant backgrounds, methylation of nonautonomous Mu elements can be reversed even in the absence of the regulatory MuDR element [2].
  • Our results suggest that the mop1 gene acts on a subset of epigenetically regulated sequences in the maize genome and paramutation and Mu element methylation require a common factor, which we hypothesize influences chromatin structure [2].
  • Although the direction and extent of paramutation is influenced by poorly understood allelic interactions occurring in diploid sporophytes, two required to maintain repression loci (rmr1 and rmr2), as well as mediator of paramutation1 (mop1), affect this process at the purple plant1 (pl1) locus [3].
  • Plants carrying mutations in the mop1 gene also stochastically exhibit pleiotropic developmental phenotypes [4].

Analytical, diagnostic and therapeutic context of MOP-1

  • Allelism tests revealed that three mutations identified two new maize loci, required to maintain repression 1 (rmr1) and rmr2 and that the other mutation represents a new allele of the previously described mediator of paramutation 1 (mop1) locus [5].


  1. mediator of paramutation1 is required for establishment and maintenance of paramutation at multiple maize loci. Dorweiler, J.E., Carey, C.C., Kubo, K.M., Hollick, J.B., Kermicle, J.L., Chandler, V.L. Plant Cell (2000) [Pubmed]
  2. A mutation that prevents paramutation in maize also reverses Mutator transposon methylation and silencing. Lisch, D., Carey, C.C., Dorweiler, J.E., Chandler, V.L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Rmr6 maintains meiotic inheritance of paramutant states in Zea mays. Hollick, J.B., Kermicle, J.L., Parkinson, S.E. Genetics (2005) [Pubmed]
  4. An RNA-dependent RNA polymerase is required for paramutation in maize. Alleman, M., Sidorenko, L., McGinnis, K., Seshadri, V., Dorweiler, J.E., White, J., Sikkink, K., Chandler, V.L. Nature (2006) [Pubmed]
  5. Genetic factors required to maintain repression of a paramutagenic maize pl1 allele. Hollick, J.B., Chandler, V.L. Genetics (2001) [Pubmed]
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