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Gene Review:

GREM2 - gremlin 2, DAN family BMP antagonist

Homo sapiens

Synonyms: CKTSF1B2, Cysteine knot superfamily 1, BMP antagonist 2, DAN domain family member 3, DAND3, FLJ21195, ...

Sudo, S. et al., Im, J. et al., Katoh, M. et al.

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High impact information on GREM2

In situ hybridization analyses further indicated that ovarian PRDC transcripts are localized in granulosa cells of selective follicles [1].
Although PRDC shows sequence homology with proteins of the BMP antagonist family, its biological activity and physiological functions are unclear [1].
In addition, co-treatment with PRDC antagonized the inhibitory effects of BMP4 on the follicle-stimulating hormone stimulation of progesterone production by cultured rat granulosa cells [1].
Protein related to DAN and cerberus (PRDC) is a secreted protein with a cystine knot structure identified by gene trapping in embryonic stem cells [1].
The PRDC induced by Wnt/beta-catenin does not inhibit Wnt signaling, but does inhibit BMP-4 signaling [2].

Biological context of GREM2

FLJ21195 (BC046632.1) was the representative human CKTSF1B2 cDNA, and CKTSF1B2 gene was mapped to human chromosome 1q43 [3].

Other interactions of GREM2

Identification and characterization of human CKTSF1B2 and CKTSF1B3 genes in silico [3].
Wnt/beta-catenin signaling regulates expression of PRDC, an antagonist of the BMP-4 signaling pathway [2].

References

Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation. Sudo, S., Avsian-Kretchmer, O., Wang, L.S., Hsueh, A.J. J. Biol. Chem. (2004) [Pubmed]
Wnt/beta-catenin signaling regulates expression of PRDC, an antagonist of the BMP-4 signaling pathway. Im, J., Kim, H., Kim, S., Jho, E.H. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
Identification and characterization of human CKTSF1B2 and CKTSF1B3 genes in silico. Katoh, M., Katoh, M. Oncol. Rep. (2004) [Pubmed]

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GREM2	Canis lupus familiaris
grem2b	Danio rerio
GREM2	Gallus gallus
GREM2	Macaca mulatta
Grem2	Mus musculus
GREM2	Pan troglodytes
Grem2	Rattus norvegicus

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