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Gene Review:

Sf3a2 - splicing factor 3a, subunit 2

Mus musculus

Synonyms: 66kDa, AW047242, PRP11, SAP 62, SF3a66, ...

Zemzoumi, K. et al., Dresser, D.W. et al., Badisa, R.B. et al., Watabe, S. et al.

Badisa, Ganeshrao, Abburi, Fatma,

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High impact information on Sf3a2

Mapping the Sf3a2 transcription start site eventually led us to locate and characterize its promoter [1].
Following purification by affinity chromatography, a Leishmania major S-hexylglutathione- binding protein of molecular mass 66kDa was isolated [2].
The immune serum against the parasite 66kDa polypeptide when used to screen a L. major cDNA library could identify clones encoding for the human v-fos transformation effector homologue, namely ribosomal protein S3a, and thus was named LmS3a-related protein (LmS3arp) [2].
The microsequence analysis revealed that the 69k and 66kDa components from the 10 degrees C-acclimated carp contained an N-terminal amino acid sequence different from that of 62kDa [3].
A single polypeptide protein of molecular weight 66kDa (MP 66), purified to homogeneity from melanosomes of normal human cadaver skin epidermal melanocytes, was further characterized [4].

Analytical, diagnostic and therapeutic context of Sf3a2

It has now been shown by RT-PCR analysis that both Sf3a2 and Gnrpx are widely expressed and therefore are likely to be 'housekeeping' genes [1].

References

An expressed GNRP-like gene shares a bi-directional promoter with SF3A2 (SAP62) immediately upstream of AMH. Dresser, D.W., Jamin, S.P., Atkins, C.J., Guerrier, D. Gene (2001) [Pubmed]
Cloning of a Leishmania major gene encoding for an antigen with extensive homology to ribosomal protein S3a. Zemzoumi, K., Guilvard, E., Sereno, D., Preto, A., Benlemlih, M., Da Silva, A.C., Lemesre, J.L., Ouaissi, A. Gene (1999) [Pubmed]
Temperature acclimation induces light meromyosin isoforms with different primary structures in carp fast skeletal muscle. Watabe, S., Imai, J., Nakaya, M., Hirayama, Y., Okamoto, Y., Masaki, H., Uozumi, T., Hirono, I., Aoki, T. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
Partial characterization of an abundant human skin melanosomal 66 kDa protein (MP 66) and investigation to purify a similar protein from B16 murine melanoma tumours. Badisa, R.B., Ganeshrao, D., Abburi, R., Fatma, T. Melanoma Res. (2000) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP011035	Anopheles gambiae str. PEST
AT2G32600	Arabidopsis thaliana
repo-1	Caenorhabditis elegans
sf3a2	Danio rerio
CG10754	Drosophila melanogaster
SF3A2	Gallus gallus
Os03g0263500	Oryza sativa Japonica Group

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