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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DNAI2  -  dynein, axonemal, intermediate chain 2

Homo sapiens

Synonyms: Axonemal dynein intermediate chain 2, CILD9, DIC2, Dynein intermediate chain 2, axonemal
 
 
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Disease relevance of DNAI2

 

High impact information on DNAI2

  • Significantly, gene expression associated with ciliogenesis is evident in bronchial epithelium, and includes the expression of transcripts specifying axonemal proteins DNAI2, SPAG6, ASP, and FOXJ1 transcription factor [2].
  • However, ten intragenic polymorphic sites and an EcoRI RFLP have been identified, allowing the exclusion of DNAI2 in three consanguineous families [1].
  • DNAI2, which is composed of 14 exons located at 17q25, is highly expressed in trachea and testis [1].

References

  1. The human dynein intermediate chain 2 gene (DNAI2): cloning, mapping, expression pattern, and evaluation as a candidate for primary ciliary dyskinesia. Pennarun, G., Chapelin, C., Escudier, E., Bridoux, A.M., Dastot, F., Cacheux, V., Goossens, M., Amselem, S., Duriez, B. Hum. Genet. (2000) [Pubmed]
  2. Identification of novel lung genes in bronchial epithelium by serial analysis of gene expression. Lonergan, K.M., Chari, R., Deleeuw, R.J., Shadeo, A., Chi, B., Tsao, M.S., Jones, S., Marra, M., Ling, V., Ng, R., Macaulay, C., Lam, S., Lam, W.L. Am. J. Respir. Cell Mol. Biol. (2006) [Pubmed]
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