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Gene Review

SH3BGRL  -  SH3 domain binding glutamate-rich protein...

Homo sapiens

Synonyms: HEL-S-115, MGC117402, SH3 domain-binding glutamic acid-rich-like protein, SH3BGR
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Disease relevance of SH3BGRL

  • As part of an effort to identify genes potentially involved in the Down Syndrome pathogenesis, in this paper we report the identification and characterization of a new human gene (named SH3BGRL), which shows a high homology to the SH3BGR gene, previously mapped to the Down Syndrome region of chromosome 21 [1].

High impact information on SH3BGRL


Other interactions of SH3BGRL

  • The protein SH3BGRL, containing both SH3-binding and Homer EVH1-binding motifs, has been crystallized using the hanging-drop vapour-diffusion method [4].
  • Crystal structure of human SH3BGRL protein: the first structure of the human SH3BGR family representing a novel class of thioredoxin fold proteins [5].

Analytical, diagnostic and therapeutic context of SH3BGRL


  1. Identification and characterization of a new human gene encoding a small protein with high homology to the proline-rich region of the SH3BGR gene. Egeo, A., Mazzocco, M., Arrigo, P., Vidal-Taboada, J.M., Oliva, R., Pirola, B., Giglio, S., Rasore-Quartino, A., Scartezzini, P. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  2. The suppression of SH3BGRL is important for v-Rel-mediated transformation. Majid, S.M., Liss, A.S., You, M., Bose, H.R. Oncogene (2006) [Pubmed]
  3. The identification of a novel human homologue of the SH3 binding glutamic acid-rich (SH3BGR) gene establishes a new family of highly conserved small proteins related to Thioredoxin Superfamily. Mazzocco, M., Maffei, M., Egeo, A., Vergano, A., Arrigo, P., Di Lisi, R., Ghiotto, F., Scartezzini, P. Gene (2002) [Pubmed]
  4. Expression, purification and crystallization of a human protein SH3BGRL at atomic resolution. Yin, L., Zhu, D.Y., Yang, N., Huang, Q.H., Zhang, Y., Wang, D.C. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2005) [Pubmed]
  5. Crystal structure of human SH3BGRL protein: the first structure of the human SH3BGR family representing a novel class of thioredoxin fold proteins. Yin, L., Xiang, Y., Zhu, D.Y., Yan, N., Huang, R.H., Zhang, Y., Wang, D.C. Proteins (2005) [Pubmed]
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