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Gene Review:

SH3BGRL3 - SH3 domain binding glutamate-rich protein...

Homo sapiens

Synonyms: HEL-S-297, P1725, SH3 domain-binding glutamic acid-rich-like protein 3, SH3 domain-binding protein 1, SH3BP-1, ...

Xu, C. et al., Mazzocco, M. et al., Mazzocco, M. et al., Khalil, A.A. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SH3BGRL3

Alb protein, peroxiredoxin 4 and SH3 domain-binding glutamic acid-rich-like protein 3 were upregulated in glioblastoma multiform versus non-tumor tissues [1].

High impact information on SH3BGRL3

These results, as a whole, indicate that SH3BGRL3 may function as a regulator in all-trans retinoic acid-induced pathway [2].
SH3BGRL and SH3BGRL3 code for small proteins similar to the N-terminal region of the SH3BGR protein [3].
The SH3BGRL3 gene was mapped to chromosome 1p34.3-35 [4].
EGFP-SH3BGRL3 fusion protein expressed in COS-7 cells localizes both to the nucleus and to the cytoplasm [4].
However, the SH3BGRL3 protein lacks both the conserved cysteine residues, which characterize the enzymatic active site of GRX [4].

Analytical, diagnostic and therapeutic context of SH3BGRL3

Immunofluorescence and immunohistochemistry staining with monoclonal antibody against SH3BGRL3 demonstrated that it was a cytoplasmic protein in both NB4 cell and human tissues [2].

References

Biomarker discovery: A proteomic approach for brain cancer profiling. Khalil, A.A., James, P. Cancer Sci. (2007) [Pubmed]
NMR structure and regulated expression in APL cell of human SH3BGRL3. Xu, C., Zheng, P., Shen, S., Xu, Y., Wei, L., Gao, H., Wang, S., Zhu, C., Tang, Y., Wu, J., Zhang, Q., Shi, Y. FEBS Lett. (2005) [Pubmed]
The identification of a novel human homologue of the SH3 binding glutamic acid-rich (SH3BGR) gene establishes a new family of highly conserved small proteins related to Thioredoxin Superfamily. Mazzocco, M., Maffei, M., Egeo, A., Vergano, A., Arrigo, P., Di Lisi, R., Ghiotto, F., Scartezzini, P. Gene (2002) [Pubmed]
A novel human homologue of the SH3BGR gene encodes a small protein similar to Glutaredoxin 1 of Escherichia coli. Mazzocco, M., Arrigo, P., Egeo, A., Maffei, M., Vergano, A., Di Lisi, R., Ghiotto, F., Ciccone, E., Cinti, R., Ravazzolo, R., Scartezzini, P. Biochem. Biophys. Res. Commun. (2001) [Pubmed]

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