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Gene Review:

Adcy5 - adenylate cyclase 5

Rattus norvegicus

Synonyms: ATP pyrophosphate-lyase 5, Adenylate cyclase type 5, Adenylate cyclase type V, Adenylyl cyclase 5

Shishido, T. et al., Ivanov, A. et al., Portela-Gomes, G.M. et al.

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High impact information on Adcy5

The EGFR-mediated increase in maxi-K(Ca) channel activity was blocked by inhibiting cAMP-dependent protein kinase (cAK) using KT-5720 or Rp-cAMP, or by inhibiting adenylate cyclase type 5 (AC-5) using 2',5'-dideoxyadenosine or knock-down of AC-5 expression by intracisternal AS-ODN [1].
Effects of repeated methamphetamine administration on dopamine D1 receptor, D2 receptor and adenylate cyclase type V mRNA levels in the rat striatum [2].
Dopamine D1 receptor (D1R), D2 receptor (D2R) and adenylate cyclase type V (AC5) mRNAs in the rat dorsal striatum (CPu) and ventral striatum (Acb) were measured by in situ hybridization histochemistry (ISHH) after repeated methamphetamine (MAP) administration [2].
In the cortex, despite the cortical hypotrophy, adenylyl cyclase 5 immunoreactivity was markedly increased in Goto-Kakizaki rats, especially in the zona reticularis [3].

References

Adenylate cyclase 5 and KCa1.1 channel are required for EGFR up-regulation of PCNA in native contractile rat basilar artery smooth muscle. Ivanov, A., Gerzanich, V., Ivanova, S., Denhaese, R., Tsymbalyuk, O., Simard, J.M. J. Physiol. (Lond.) (2006) [Pubmed]
Effects of repeated methamphetamine administration on dopamine D1 receptor, D2 receptor and adenylate cyclase type V mRNA levels in the rat striatum. Shishido, T., Watanabe, Y., Suzuki, H., Kato, K., Niwa, S., Hanoune, J., Matsuoka, I. Neurosci. Lett. (1997) [Pubmed]
Increased expression of adenylyl cyclase isoforms in the adrenal gland of diabetic Goto-Kakizaki rat. Portela-Gomes, G.M., Grimelius, L., Johansson, H., Efendic, S., Wester, K., Abdel-Halim, S.M. Appl. Immunohistochem. Mol. Morphol. (2002) [Pubmed]

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AgaP_AGAP002998	Anopheles gambiae str. PEST
ADCY5	Bos taurus
acy-4	Caenorhabditis elegans
ADCY5	Canis lupus familiaris
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CG43373	Drosophila melanogaster
ADCY5	Gallus gallus
ADCY5	Homo sapiens
ADCY5	Macaca mulatta
Adcy5	Mus musculus
ADCY5	Pan troglodytes

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