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Gene Review: 

Spef2  -  sperm flagellar 2

Rattus norvegicus

Synonyms: Kpl2, Protein KPL2, Sperm flagellar protein 2
 
 
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High impact information on Kpl2

  • KPL2 was undetectable in heart and liver samples, but was expressed in brain and testis, tissues that contain axonemal structures [1].
  • KPL2 contains a long open reading frame predicted to code for a protein of > 200 kD [1].
  • Several putative functional motifs are present in the protein, including a calponin homology domain, three nuclear localization signals, a consensus P-loop, and a proline-rich region, suggesting that KPL2 has a unique function [1].
  • Cloning and characterization of KPL2, a novel gene induced during ciliogenesis of tracheal epithelial cells [1].
  • In seminiferous tubules of the testis, KPL2 expression was stage-specific and appeared to be highest in spermatocytes and round spermatids [1].
 

Analytical, diagnostic and therapeutic context of Kpl2

  • One of these, KPL2, detected a messenger RNA transcript of approximately 6 kb when used as a probe on Northern blots of RNA from ciliated cultures but was undetectable in RNA from nonciliated cultures [1].

References

  1. Cloning and characterization of KPL2, a novel gene induced during ciliogenesis of tracheal epithelial cells. Ostrowski, L.E., Andrews, K., Potdar, P., Matsuura, H., Jetten, A., Nettesheim, P. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
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