Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

PLA2G2F - phospholipase A2, group IIF

Homo sapiens

Synonyms: GIIF sPLA2, Group IIF secretory phospholipase A2, Phosphatidylcholine 2-acylhydrolase 2F, sPLA2-IIF

Murakami, M. et al.

Murakami, Yoshihara, Shimbara, Lambeau, Gelb, Singer, Sawada, Inagaki, Nagai, Ishihara, Ishikawa, Ishii, Kudo,

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Disease relevance of PLA2G2F

The unique C-terminal extension was crucial for its plasma membrane localization and optimal cellular functions. sPLA(2)-IIF expression was increased in various tissues from lipopolysaccharide-treated mice and in ears of mice with experimental atopic dermatitis [1].

High impact information on PLA2G2F

AA release by sPLA(2)-IIF was facilitated by oxidative modification of cellular membranes [1].
In human rheumatoid arthritic joints, sPLA(2)-IIF was detected in synovial lining cells, capillary endothelial cells, and plasma cells [1].
Cellular actions of sPLA(2)-IIF occurred independently of the heparan sulfate proteoglycan glypican, which acts as a functional adaptor for other group II subfamily sPLA(2)s. Confocal microscopy revealed the location of sPLA(2)-IIF on the plasma membrane [1].

References

Cellular arachidonate-releasing function and inflammation-associated expression of group IIF secretory phospholipase A2. Murakami, M., Yoshihara, K., Shimbara, S., Lambeau, G., Gelb, M.H., Singer, A.G., Sawada, M., Inagaki, N., Nagai, H., Ishihara, M., Ishikawa, Y., Ishii, T., Kudo, I. J. Biol. Chem. (2002) [Pubmed]

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