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Gene Review

ctsd  -  cathepsin D

Danio rerio

Synonyms: SO:0000704, catD, fb93e11, fj17b09, wu:fb93e11, ...
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High impact information on ctsd

  • One of the two cDNAs was a 1708 bp product with an open reading frame of 398 amino acid residues corresponding to a cathepsin D. The other was a 1383 bp product encoding a polypeptide chain of 416 amino acids homologous to nothepsin, an aspartic proteinase first identified by us in the liver of Antarctic Notothenioidei [1].
  • The embryonic cathepsin D (CAT D) activity, eggshell thickness, fecundity, hatching rate and malformation (vertebral column flexure) rate of offspring were determined in the four pair-bred groups [2].


  1. Sex- and tissue-specific expression of aspartic proteinases in Danio rerio (zebrafish). Riggio, M., Scudiero, R., Filosa, S., Parisi, E. Gene (2000) [Pubmed]
  2. Reproductive effects of prenatal exposure to nonylphenol on zebrafish (Danio rerio). Yang, F.X., Xu, Y., Hui, Y. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2006) [Pubmed]
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