Gene Review:
Ctsd - cathepsin D
Mus musculus
Synonyms:
CD, CatD, Cathepsin D
- Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation. Egberts, F., Heinrich, M., Jensen, J.M., Winoto-Morbach, S., Pfeiffer, S., Wickel, M., Schunck, M., Steude, J., Saftig, P., Proksch, E., Schütze, S. J. Cell. Sci. (2004)
- Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice. Nakanishi, H., Zhang, J., Koike, M., Nishioku, T., Okamoto, Y., Kominami, E., von Figura, K., Peters, C., Yamamoto, K., Saftig, P., Uchiyama, Y. J. Neurosci. (2001)
- Cutting edge: a novel nonoxidative phagosomal mechanism exerted by cathepsin-D controls Listeria monocytogenes intracellular growth. del Cerro-Vadillo, E., Madrazo-Toca, F., Carrasco-Marín, E., Fernandez-Prieto, L., Beck, C., Leyva-Cobián, F., Saftig, P., Alvarez-Dominguez, C. J. Immunol. (2006)
- Proteolytic degradation of glutamate decarboxylase mediates disinhibition of hippocampal CA3 pyramidal cells in cathepsin D-deficient mice. Shimizu, T., Hayashi, Y., Yamasaki, R., Yamada, J., Zhang, J., Ukai, K., Koike, M., Mine, K., von Figura, K., Peters, C., Saftig, P., Fukuda, T., Uchiyama, Y., Nakanishi, H. J. Neurochem. (2005)
- Cathepsin D-mediated proteolysis of apolipoprotein E: Possible role in Alzheimer's disease. Zhou, W., Scott, S.A., Shelton, S.B., Crutcher, K.A. Neuroscience (2006)
- Combined effects of fasting and vinblastine treatment on serum insulin level, the size of autophagic-lysosomal compartment, protein content and lysosomal enzyme activities of liver and exocrine pancreatic cells of the mouse. Kovács, A.L., László, L., Fellinger, E., Jakab, A., Orosz, A., Réz, G., Kovács, J. Comp. Biochem. Physiol., B (1989)
- Legionella pneumophila replication vacuoles mature into acidic, endocytic organelles. Sturgill-Koszycki, S., Swanson, M.S. J. Exp. Med. (2000)
- Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells. Baram, D., Adachi, R., Medalia, O., Tuvim, M., Dickey, B.F., Mekori, Y.A., Sagi-Eisenberg, R. J. Exp. Med. (1999)
- The giant organelles in beige and Chediak-Higashi fibroblasts are derived from late endosomes and mature lysosomes. Burkhardt, J.K., Wiebel, F.A., Hester, S., Argon, Y. J. Exp. Med. (1993)
- Various enzyme activities in muscle and other organs of dystrophic mice. Aoyagi, T., Wada, T., Kojima, F., Nagai, M., Umezawa, H. J. Clin. Invest. (1981)
- Effects of inhibition of microtubule assembly on bone mineral release and enzyme release by human breast cancer cells. Eilon, G., Mundy, G.R. J. Clin. Invest. (1981)
- Decreased secretion of Cathepsin D in breast cancer in vivo by tamoxifen: mediated by the mannose-6-phosphate/IGF-II receptor? Dabrosin, C., Johansson, A.C., Ollinger, K. Breast Cancer Res. Treat. (2004)
- Antimetastatic activity of adriamycin in combinations with proteinase inhibitors in mice. Leto, G., Tumminello, F.M., Gebbia, N., Woynarowska, B., Bernacki, R.J. Anticancer Res. (1990)
- Protective effects of PGE2 on diet-induced acute pancreatitis in mice. Manabe, T., Steer, M.L. Gastroenterology (1980)
- Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells. Krishnan, V., Porter, W., Santostefano, M., Wang, X., Safe, S. Mol. Cell. Biol. (1995)
- Evidence that Dot-dependent and -independent factors isolate the Legionella pneumophila phagosome from the endocytic network in mouse macrophages. Joshi, A.D., Sturgill-Koszycki, S., Swanson, M.S. Cell. Microbiol. (2001)
- Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia. Nishioku, T., Hashimoto, K., Yamashita, K., Liou, S.Y., Kagamiishi, Y., Maegawa, H., Katsube, N., Peters, C., von Figura, K., Saftig, P., Katunuma, N., Yamamoto, K., Nakanishi, H. J. Biol. Chem. (2002)
- Cathepsin D, but not cathepsin B, releases T cell stimulatory fragments from lysozyme that are functional in the context of multiple murine class II MHC molecules. van Noort, J.M., Jacobs, M.J. Eur. J. Immunol. (1994)
- Modulation of cathepsin D routing by IGF-II involves IGF-II binding to IGF-II/M6P receptor in MCF-7 breast cancer cells. Faridi, J.S., Mohan, S., De León, D.D. Growth Factors (2004)
- Gene expression profiling of cathepsin D, metallothioneins-1 and -2, osteopontin, and tenascin-C in a mouse spinal cord injury model by cDNA microarray analysis. Hashimoto, M., Koda, M., Ino, H., Yoshinaga, K., Murata, A., Yamazaki, M., Kojima, K., Chiba, K., Mori, C., Moriya, H. Acta Neuropathol. (2005)
- Uptake of oxidized LDL by macrophages results in partial lysosomal enzyme inactivation and relocation. Li, W., Yuan, X.M., Olsson, A.G., Brunk, U.T. Arterioscler. Thromb. Vasc. Biol. (1998)
- Cathepsin D is specifically inhibited by deoxyribonucleic acids. Shibata, M., Koike, M., Waguri, S., Zhang, G., Koga, T., Uchiyama, Y. FEBS Lett. (2002)
- II. Characterization and development of the regional- and cellular-specific abnormalities in the epididymis of mice with beta-hexosaminidase A deficiency. Adamali, H.I., Somani, I.H., Huang, J.Q., Gravel, R.A., Trasler, J.M., Hermo, L. J. Androl. (1999)
- Cathepsin D targeted by acid sphingomyelinase-derived ceramide. Heinrich, M., Wickel, M., Schneider-Brachert, W., Sandberg, C., Gahr, J., Schwandner, R., Weber, T., Saftig, P., Peters, C., Brunner, J., Krönke, M., Schütze, S. EMBO J. (1999)
- Anion-exchange blocker enhances cytoplasmic vacuole formation and cell death in serum-deprived mouse kidney epithelial cells in mice. Araki, T., Hayashi, M., Saruta, T. Cell Biol. Int. (2006)
- Endosomal-lysosomal proteolysis mediates death signalling by TNFalpha, not by etoposide, in L929 fibrosarcoma cells: evidence for an active role of cathepsin D. Démoz, M., Castino, R., Cesaro, P., Baccino, F.M., Bonelli, G., Isidoro, C. Biol. Chem. (2002)
- Loss of dopaminergic neurons by the induction of inducible nitric oxide synthase and cyclooxygenase-2 via CD 40: relevance to Parkinson's disease. Okuno, T., Nakatsuji, Y., Kumanogoh, A., Moriya, M., Ichinose, H., Sumi, H., Fujimura, H., Kikutani, H., Sakoda, S. J. Neurosci. Res. (2005)
- A casein kinase II phosphorylation site in the cytoplasmic domain of the cation-dependent mannose 6-phosphate receptor determines the high affinity interaction of the AP-1 Golgi assembly proteins with membranes. Mauxion, F., Le Borgne, R., Munier-Lehmann, H., Hoflack, B. J. Biol. Chem. (1996)
- Induction of avascular yolk sac due to reduction of basic fibroblast growth factor by retinoic acid in mice. Yasuda, Y., Nishi, N., Takahashi, J.A., Konishi, H., Ohara, I., Fujita, H., Ohta, M., Itoh, N., Hatanaka, M., Tanimura, T. Dev. Biol. (1992)
- The cytoplasmic tail of the mannose 6-phosphate/insulin-like growth factor-II receptor has two signals for lysosomal enzyme sorting in the Golgi. Johnson, K.F., Kornfeld, S. J. Cell Biol. (1992)
- Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells. Saftig, P., Hetman, M., Schmahl, W., Weber, K., Heine, L., Mossmann, H., Köster, A., Hess, B., Evers, M., von Figura, K. EMBO J. (1995)
- Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons. Koike, M., Nakanishi, H., Saftig, P., Ezaki, J., Isahara, K., Ohsawa, Y., Schulz-Schaeffer, W., Watanabe, T., Waguri, S., Kametaka, S., Shibata, M., Yamamoto, K., Kominami, E., Peters, C., von Figura, K., Uchiyama, Y. J. Neurosci. (2000)
- Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). Koike, M., Shibata, M., Waguri, S., Yoshimura, K., Tanida, I., Kominami, E., Gotow, T., Peters, C., von Figura, K., Mizushima, N., Saftig, P., Uchiyama, Y. Am. J. Pathol. (2005)
- Molecular cloning of mouse cathepsin D. Grusby, M.J., Mitchell, S.C., Glimcher, L.H. Nucleic Acids Res. (1990)