Gene Review:
Psenen - presenilin enhancer 2 homolog (C. elegans)
Mus musculus
Synonyms:
1700023M09Rik, Gamma-secretase subunit PEN-2, Pen-2, Pen2, Presenilin enhancer protein 2
- Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis. Laudon, H., Karlström, H., Mathews, P.M., Farmery, M.R., Gandy, S.E., Lundkvist, J., Lendahl, U., Näslund, J. J. Biol. Chem. (2004)
- Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin. Nyabi, O., Bentahir, M., Horré, K., Herreman, A., Gottardi-Littell, N., Van Broeckhoven, C., Merchiers, P., Spittaels, K., Annaert, W., De Strooper, B. J. Biol. Chem. (2003)
- Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation. Crystal, A.S., Morais, V.A., Fortna, R.R., Carlin, D., Pierson, T.C., Wilson, C.A., Lee, V.M., Doms, R.W. Biochemistry (2004)