The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Psenen  -  presenilin enhancer 2 homolog (C. elegans)

Mus musculus

Synonyms: 1700023M09Rik, Gamma-secretase subunit PEN-2, Pen-2, Pen2, Presenilin enhancer protein 2
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Psenen

  • All three mutant PS1 molecules were incorporated into gamma-secretase complexes and stabilized Pen-2 in PS null cells [1].
  • Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin [2].
 

Analytical, diagnostic and therapeutic context of Psenen

References

  1. Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis. Laudon, H., Karlström, H., Mathews, P.M., Farmery, M.R., Gandy, S.E., Lundkvist, J., Lendahl, U., Näslund, J. J. Biol. Chem. (2004) [Pubmed]
  2. Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin. Nyabi, O., Bentahir, M., Horré, K., Herreman, A., Gottardi-Littell, N., Van Broeckhoven, C., Merchiers, P., Spittaels, K., Annaert, W., De Strooper, B. J. Biol. Chem. (2003) [Pubmed]
  3. Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation. Crystal, A.S., Morais, V.A., Fortna, R.R., Carlin, D., Pierson, T.C., Wilson, C.A., Lee, V.M., Doms, R.W. Biochemistry (2004) [Pubmed]
 
WikiGenes - Universities