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Gene Review

SNRPE  -  small nuclear ribonucleoprotein polypeptide E

Homo sapiens

Synonyms: B-raf, HYPT11, SME, Sm protein E, Sm-E, ...
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High impact information on SNRPE

  • Moreover, Gemin7 interacts with several Sm proteins of spliceosomal small nuclear ribonucleoproteins, in particular, with SmE [1].
  • By transfection of constructs containing various amounts of the 5'-upstream region of the snRNP E protein gene linked to the bacterial gene for chloramphenicol acetyl transferase (CAT), we determined that the 5' boundary of sequence needed for transcription was within the first 153 nucleotides upstream of the transcription start site [2].
  • This suggests that the direct repeats of the CTTCCG hexamer sequence play a key role in transcriptional regulation of the snRNP E protein gene [2].
  • The small nuclear ribonucleoprotein E protein gene contains four introns and has upstream similarities to genes for ribosomal proteins [3].
  • An EcoO109 RFLP for the SNRPE gene on chromosome 1 [4].

Biological context of SNRPE


Analytical, diagnostic and therapeutic context of SNRPE


  1. Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex. Baccon, J., Pellizzoni, L., Rappsilber, J., Mann, M., Dreyfuss, G. J. Biol. Chem. (2002) [Pubmed]
  2. Transcriptional regulation of the small nuclear ribonucleoprotein E protein gene. Identification of cis-acting sequences with homology to genes encoding ribosomal proteins. Fautsch, M.P., Wieben, E.D. J. Biol. Chem. (1991) [Pubmed]
  3. The small nuclear ribonucleoprotein E protein gene contains four introns and has upstream similarities to genes for ribosomal proteins. Stanford, D.R., Perry, C.A., Holicky, E.L., Rohleder, A.M., Wieben, E.D. J. Biol. Chem. (1988) [Pubmed]
  4. An EcoO109 RFLP for the SNRPE gene on chromosome 1. Miller, B.L., Nishimura, D.Y., Wieben, E.D., Murray, J.C. Nucleic Acids Res. (1991) [Pubmed]
  5. Assignment of the gene for the small nuclear ribonucleoprotein E (SNRPE) to human chromosome 1q25-q43. Neiswanger, K., Stanford, D.R., Sparkes, R.S., Nishimura, D., Mohandas, T., Klisak, I., Heinzmann, C., Wieben, E.D. Genomics (1990) [Pubmed]
  6. A U6 snRNA gene with an internal promoter is juxtaposed to an snRNP protein sequence within an intron of a human G protein gene. Wieben, E.D., Vrabel, A.M., Holicky, E.L., Klisak, I., Sparkes, R.S., Stanford, D.R. Nucleic Acids Res. (1991) [Pubmed]
  7. The snRNP E protein multigene family contains five pseudogenes with common mutations. Stanford, D.R., Holicky, E.L., Perry, C.A., Rehder, K., Harvey, S.E., Rohleder, A.M., Wieben, E.D. DNA Seq. (1991) [Pubmed]
  8. B-raf oncogene: activation by rearrangements and assignment to human chromosome 7. Kamiyama, T., Aoki, N., Yuasa, Y. Jpn. J. Cancer Res. (1993) [Pubmed]
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