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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GEMIN7  -  gem (nuclear organelle) associated protein 7

Homo sapiens

Synonyms: FLJ13956, Gem-associated protein 7, Gemin-7, SIP3
 
 
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Disease relevance of GEMIN7

  • ZNF342 expression is specifically decreased in primary oligodendrogliomas and up-regulated in glioma cell lines treated with a demethylating agent, whereas the expression level of the adjacent gene, Gemin7, is not consistently altered in these samples [1].
 

High impact information on GEMIN7

  • In the latter case, unrip is recruited to the active SMN complex via a stable interaction with Gemin7 [2].
  • Gemin8 binds directly to SMN and mediates its interaction with the Gemin6/Gemin7 heterodimer [3].
  • Moreover, Gemin7 interacts with several Sm proteins of spliceosomal small nuclear ribonucleoproteins, in particular, with SmE [4].
  • Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex [4].
  • The amino acid sequence of Gemin7 does not contain any recognizable motifs with the exception of several arginine and glycine repeats that are necessary for its interaction with SMN [4].
 

Physical interactions of GEMIN7

  • Binding experiments show that Gemin7 interacts directly with SMN and Gemin6 and mediates the association of Gemin6 with the SMN complex [4].

References

  1. The contribution of genetic and epigenetic mechanisms to gene silencing in oligodendrogliomas. Hong, C., Bollen, A.W., Costello, J.F. Cancer Res. (2003) [Pubmed]
  2. Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization. Grimmler, M., Otter, S., Peter, C., Müller, F., Chari, A., Fischer, U. Hum. Mol. Genet. (2005) [Pubmed]
  3. Gemin8 is required for the architecture and function of the survival motor neuron complex. Carissimi, C., Saieva, L., Gabanella, F., Pellizzoni, L. J. Biol. Chem. (2006) [Pubmed]
  4. Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex. Baccon, J., Pellizzoni, L., Rappsilber, J., Mann, M., Dreyfuss, G. J. Biol. Chem. (2002) [Pubmed]
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