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Gene Review:

Snx9 - sorting nexin 9

Mus musculus

Synonyms: 2700073N08Rik, SDP1, SH3PX1, Sorting nexin-9

Shimizu, E. et al., Yang, W. et al., MaCaulay, S.L. et al.

MaCaulay, Stoichevska, Grusovin, Gough, Castelli, Ward, Yang, Jansen, Lin, Canova, Cerione, Childress,

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High impact information on Snx9

The cytoplasmic domain comprises 103 amino acids containing proline-rich endophilin I, Src homology 3 (SH3), and phox homology domain-containing protein (SH3PX1) binding motifs [1].
ACK2 interacts with clathrin, an endocytic vesicle coating protein, and SH3PX1, a sorting nexin, and is involved in clathrin-mediated endocytosis [2].
SNX9 (sorting nexin 9) is one member of a family of proteins implicated in protein trafficking [3].

References

Structure and expression of the murine ADAM 15 gene and its splice variants, and difference of interaction between their cytoplasmic domains and Src family proteins. Shimizu, E., Yasui, A., Matsuura, K., Hijiya, N., Higuchi, Y., Yamamoto, S. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
Interaction of activated Cdc42-associated tyrosine kinase ACK2 with HSP90. Yang, W., Jansen, J.M., Lin, Q., Canova, S., Cerione, R.A., Childress, C. Biochem. J. (2004) [Pubmed]
Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action. MaCaulay, S.L., Stoichevska, V., Grusovin, J., Gough, K.H., Castelli, L.A., Ward, C.W. Biochem. J. (2003) [Pubmed]

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