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Gene Review

Sh3gl2  -  SH3-domain GRB2-like 2

Mus musculus

Synonyms: 9530001L19Rik, AI120490, AW555077, B930049H17Rik, EEN-B1, ...
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High impact information on Sh3gl2

  • Endophilin I exhibits lysophosphatidic acid acyl transferase (LPAAT) activity, and endophilin-I-mediated SLMV formation requires the transfer of the unsaturated fatty acid arachidonate to lysophosphatidic acid, converting it to phosphatidic acid [1].
  • These studies show that Arc/Arg3.1 regulates endophilin 3 and dynamin 2, two components of the endocytosis machinery [2].
  • Consistent with this, immunofluorescence analysis of endophilin B1b transfected into fibroblasts shows an intracellular reticular staining, which in part overlaps with that of endogenous dynamin [3].
  • The protein was named RICH-1 (RhoGAP interacting with CIP4 homologues), and, in addition to the RhoGAP domain, it contained an N-terminal domain with endophilin homology and a C-terminal proline-rich domain [4].
  • The site of interaction was suggested to be the SH-3-binding domain of Mta1 and SH-3 domain of endophilin 3 [5].

Biological context of Sh3gl2


Anatomical context of Sh3gl2


Other interactions of Sh3gl2

  • The cytoplasmic domain comprises 103 amino acids containing proline-rich endophilin I, Src homology 3 (SH3), and phox homology domain-containing protein (SH3PX1) binding motifs [8].


  1. Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid. Schmidt, A., Wolde, M., Thiele, C., Fest, W., Kratzin, H., Podtelejnikov, A.V., Witke, W., Huttner, W.B., Söling, H.D. Nature (1999) [Pubmed]
  2. Arc/Arg3.1: linking gene expression to synaptic plasticity and memory. Tzingounis, A.V., Nicoll, R.A. Neuron (2006) [Pubmed]
  3. Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1. Modregger, J., Schmidt, A.A., Ritter, B., Huttner, W.B., Plomann, M. J. Biol. Chem. (2003) [Pubmed]
  4. Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1. Richnau, N., Aspenström, P. J. Biol. Chem. (2001) [Pubmed]
  5. Direct interaction between metastasis-associated protein 1 and endophilin 3. Aramaki, Y., Ogawa, K., Toh, Y., Ito, T., Akimitsu, N., Hamamoto, H., Sekimizu, K., Matsusue, K., Kono, A., Iguchi, H., Takiguchi, S. FEBS Lett. (2005) [Pubmed]
  6. Alix, making a link between apoptosis-linked gene-2, the endosomal sorting complexes required for transport, and neuronal death in vivo. Mahul-Mellier, A.L., Hemming, F.J., Blot, B., Fraboulet, S., Sadoul, R. J. Neurosci. (2006) [Pubmed]
  7. Crystal structure of the endophilin-A1 BAR domain. Weissenhorn, W. J. Mol. Biol. (2005) [Pubmed]
  8. Structure and expression of the murine ADAM 15 gene and its splice variants, and difference of interaction between their cytoplasmic domains and Src family proteins. Shimizu, E., Yasui, A., Matsuura, K., Hijiya, N., Higuchi, Y., Yamamoto, S. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
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