The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SPAG4  -  sperm associated antigen 4

Homo sapiens

Synonyms: CT127, Outer dense fiber-associated protein SPAG4, SUN domain-containing protein 4, SUN4, Sperm-associated antigen 4 protein
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on SPAG4

  • Our data suggest a role for Spag4 in protein localization to two major sperm tail structures [1].
  • Spag4 is detectable in the transient manchette and it is associated with the axoneme in elongating spermatids and epididymal sperm [1].
  • SPAG4 is a 12-exon gene spanning approximately 5.2 kb on chromosome 20q11.23 [2].
  • Using a combination of database screening and polymerase chain reaction analyses we have determined the sequence and structure of the human sperm tail associated gene SPAG4 [2].
  • The product of the spermatid-specific rat SPAG4 gene interacts specifically with the major 27-kDa outer dense fiber protein ODF27 in elongating spermatids [3].

Biological context of SPAG4


Analytical, diagnostic and therapeutic context of SPAG4


  1. Spag4, a novel sperm protein, binds outer dense-fiber protein Odf1 and localizes to microtubules of manchette and axoneme. Shao, X., Tarnasky, H.A., Lee, J.P., Oko, R., van der Hoorn, F.A. Dev. Biol. (1999) [Pubmed]
  2. Human sperm associated antigen 4 (SPAG4) is a potential cancer marker. Kennedy, C., Sebire, K., de Kretser, D.M., O'Bryan, M.K. Cell Tissue Res. (2004) [Pubmed]
  3. A novel testis-specific gene, SPAG4, whose product interacts specifically with outer dense fiber protein ODF27, maps to human chromosome 20q11.2. Tarnasky, H., Gill, D., Murthy, S., Shao, X., Demetrick, D.J., van der Hoorn, F.A. Cytogenet. Cell Genet. (1998) [Pubmed]
WikiGenes - Universities