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Gene Review:

SPAG4 - sperm associated antigen 4

Homo sapiens

Synonyms: CT127, Outer dense fiber-associated protein SPAG4, SUN domain-containing protein 4, SUN4, Sperm-associated antigen 4 protein

Tarnasky, H. et al., Kennedy, C. et al., Shao, X. et al.

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High impact information on SPAG4

Our data suggest a role for Spag4 in protein localization to two major sperm tail structures [1].
Spag4 is detectable in the transient manchette and it is associated with the axoneme in elongating spermatids and epididymal sperm [1].
SPAG4 is a 12-exon gene spanning approximately 5.2 kb on chromosome 20q11.23 [2].
Using a combination of database screening and polymerase chain reaction analyses we have determined the sequence and structure of the human sperm tail associated gene SPAG4 [2].
The product of the spermatid-specific rat SPAG4 gene interacts specifically with the major 27-kDa outer dense fiber protein ODF27 in elongating spermatids [3].

Biological context of SPAG4

A novel testis-specific gene, SPAG4, whose product interacts specifically with outer dense fiber protein ODF27, maps to human chromosome 20q11.2 [3].

Analytical, diagnostic and therapeutic context of SPAG4

In this study we isolated the human homolog of the spermatid-specific rat SPAG4 gene and mapped it by fluorescence in situ hybridization to chromosome 20q11.2 [3].

References

Spag4, a novel sperm protein, binds outer dense-fiber protein Odf1 and localizes to microtubules of manchette and axoneme. Shao, X., Tarnasky, H.A., Lee, J.P., Oko, R., van der Hoorn, F.A. Dev. Biol. (1999) [Pubmed]
Human sperm associated antigen 4 (SPAG4) is a potential cancer marker. Kennedy, C., Sebire, K., de Kretser, D.M., O'Bryan, M.K. Cell Tissue Res. (2004) [Pubmed]
A novel testis-specific gene, SPAG4, whose product interacts specifically with outer dense fiber protein ODF27, maps to human chromosome 20q11.2. Tarnasky, H., Gill, D., Murthy, S., Shao, X., Demetrick, D.J., van der Hoorn, F.A. Cytogenet. Cell Genet. (1998) [Pubmed]

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LOC100911109	Rattus norvegicus

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