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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Cdt1  -  chromatin licensing and DNA replication...

Mus musculus

Synonyms: 2610318F11Rik, AW545653, C76791, DNA replication factor Cdt1, DUP, ...
 
 
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High impact information on Cdt1

  • E(2) caused this chromatin loading by retention of MCM proteins in the nucleus and through the induction of the loading factor Cdt1, which is necessary for the MCM heterohexamer to bind to the origin of DNA replication [1].
  • GMN-1 inhibits not only the interaction between mouse Cdt1 and Mcm6 but also licensing activity in Xenopus egg extracts [2].
  • Consistently, NIH3T3 fibroblasts overexpressing Ris2 formed tumors in Rag2 -/- mice when injected subcutaneously [3].
  • Ris2 was also expressed at high levels in all human tumor cell lines analysed [3].
  • Geminin has been thought to serve as a central mediator of this licensing mechanism by binding to and antagonizing the function of Cdt1 and thereby preventing re-replication during S and G(2) phases [4].
 

Biological context of Cdt1

  • The putative RIS2 protein shows a high sequence similarity to Xenopus CDT1, Drosophila DUP, and human CDT1, a newly identified DNA replication licensing protein, suggesting that Ris2 is a mouse homologue of CDT1 [3].
  • The cell-cycle regulator geminin controls replication by binding to the licensing factor Cdt1, and is involved in neural differentiation [5].
 

Physical interactions of Cdt1

  • Geminin binds tightly to Cdt1, an essential component of the replication licensing system, and prevents the inappropriate reinitiation of replication on an already fired origin [6].
 

Regulatory relationships of Cdt1

  • DNA binding and helicase activities of Mcm4/6/7 are significantly stimulated by Cdt1 protein in vitro [7].

References

  1. Progesterone blocks estrogen-induced DNA synthesis through the inhibition of replication licensing. Pan, H., Deng, Y., Pollard, J.W. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development. Yanagi, K., Mizuno, T., Tsuyama, T., Tada, S., Iida, Y., Sugimoto, A., Eki, T., Enomoto, T., Hanaoka, F. J. Biol. Chem. (2005) [Pubmed]
  3. Oncogenic potential of the DNA replication licensing protein CDT1. Arentson, E., Faloon, P., Seo, J., Moon, E., Studts, J.M., Fremont, D.H., Choi, K. Oncogene (2002) [Pubmed]
  4. Geminin is essential for the development of preimplantation mouse embryos. Hara, K., Nakayama, K.I., Nakayama, K. Genes Cells (2006) [Pubmed]
  5. The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. Luo, L., Yang, X., Takihara, Y., Knoetgen, H., Kessel, M. Nature (2004) [Pubmed]
  6. Structural basis for inhibition of the replication licensing factor Cdt1 by geminin. Lee, C., Hong, B., Choi, J.M., Kim, Y., Watanabe, S., Ishimi, Y., Enomoto, T., Tada, S., Kim, Y., Cho, Y. Nature (2004) [Pubmed]
  7. Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity. You, Z., Masai, H. J. Biol. Chem. (2008) [Pubmed]
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