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Gene Review

Gmnn  -  geminin

Mus musculus

Synonyms: AW546347, Gem, Geminin
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High impact information on Gmnn


Biological context of Gmnn


Anatomical context of Gmnn

  • Similarly, an acute loss of Rb in mouse adult fibroblasts deregulated geminin RNA and protein levels [3].

Physical interactions of Gmnn

  • Geminin binds tightly to Cdt1, an essential component of the replication licensing system, and prevents the inappropriate reinitiation of replication on an already fired origin [6].

Other interactions of Gmnn

  • Initially, we observed that the activation of RB led to the repression of geminin transcription [3].
  • Structural basis for inhibition of the replication licensing factor Cdt1 by geminin [6].
  • This licensing control is achieved through the activities of geminin and cyclin-dependent kinases [6].


  1. Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development. Gonzalez, M.A., Tachibana, K.E., Adams, D.J., van der Weyden, L., Hemberger, M., Coleman, N., Bradley, A., Laskey, R.A. Genes Dev. (2006) [Pubmed]
  2. Cell cycle and developmental regulations of replication factors in mouse embryonic stem cells. Fujii-Yamamoto, H., Kim, J.M., Arai, K., Masai, H. J. Biol. Chem. (2005) [Pubmed]
  3. Geminin is targeted for repression by the retinoblastoma tumor suppressor pathway through intragenic E2F sites. Markey, M., Siddiqui, H., Knudsen, E.S. J. Biol. Chem. (2004) [Pubmed]
  4. Geminin is essential for the development of preimplantation mouse embryos. Hara, K., Nakayama, K.I., Nakayama, K. Genes Cells (2006) [Pubmed]
  5. Comparison of herpes simplex virus reactivation in ganglia in vivo and in explants demonstrates quantitative and qualitative differences. Sawtell, N.M., Thompson, R.L. J. Virol. (2004) [Pubmed]
  6. Structural basis for inhibition of the replication licensing factor Cdt1 by geminin. Lee, C., Hong, B., Choi, J.M., Kim, Y., Watanabe, S., Ishimi, Y., Enomoto, T., Tada, S., Kim, Y., Cho, Y. Nature (2004) [Pubmed]
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