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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Kat8  -  K(lysine) acetyltransferase 8

Mus musculus

Synonyms: 2010203C02Rik, 5830450F21Rik, D7Ertd629e, Histone acetyltransferase KAT8, Lysine acetyltransferase 8, ...
 
 
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Disease relevance of Myst1

  • From mice and MOF: rodent models, immune modulation, and outcome in the critically ill [1].
 

High impact information on Myst1

  • Querkopf, a MYST family histone acetyltransferase, is required for normal cerebral cortex development [2].
  • Among the MYST family, this zinc finger, or zinc finger-like domain, is responsible for making contacts with the histone tails within nucleosomes for the HAT to catalyze its respective reaction [3].
 

Analytical, diagnostic and therapeutic context of Myst1

  • The accumulation of metabolites is thought to be responsible for nephrotoxicity of MOF; therefore, D-MOF should be a much safer agent for use in general anesthesia [4].

References

  1. From mice and MOF: rodent models, immune modulation, and outcome in the critically ill. Bauer, M., Reinhart, K. Crit. Care Med. (2006) [Pubmed]
  2. Querkopf, a MYST family histone acetyltransferase, is required for normal cerebral cortex development. Thomas, T., Voss, A.K., Chowdhury, K., Gruss, P. Development (2000) [Pubmed]
  3. The histone acetyltransferase NCOAT contains a zinc finger-like motif involved in substrate recognition. Toleman, C.A., Paterson, A.J., Kudlow, J.E. J. Biol. Chem. (2006) [Pubmed]
  4. Perdeuteration of methoxyflurane reduces production of fluorometabolites in mice. Fry, B.W., Ciarlone, A.E. Res. Commun. Chem. Pathol. Pharmacol. (1990) [Pubmed]
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