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Gene Review

Kat6b  -  K(lysine) acetyltransferase 6B

Mus musculus

Synonyms: AI507552, B130044K16Rik, Histone acetyltransferase KAT6B, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4, MYST-4, ...
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Disease relevance of Myst4


High impact information on Myst4

  • Furthermore, the selective depletion of the population of this stem cell in querkopf mutant mice (which are deficient in production of olfactory neurons) suggests that it acts as a major functional stem cell in vivo [5].
  • Furthermore, the mixed populations of cells in culture and in the tumors phenotypically resembled the leukemic cells from patients with monocytic leukemia with histiocytic differentiation (acute myeloid leukemia-M5c), a newly proposed subtype of myeloid leukemia [6].
  • Querkopf, a MYST family histone acetyltransferase, is required for normal cerebral cortex development [1].
  • Our results suggest that Querkopf is an essential component of a genetic cascade regulating cell differentiation in the cortex, probably acting in a multiprotein complex regulating chromatin structure during transcription [1].
  • We purified from activated T lymphocytes a novel, highly conserved, 116-kDa, intracellular protein that occurred at high levels in the large, dividing cells of the thymus, was up-regulated when resting T or B lymphocytes or hemopoietic progenitors were activated, and was down-regulated when a monocytic leukemia, M1, was induced to differentiate [7].

Biological context of Myst4


Anatomical context of Myst4


Associations of Myst4 with chemical compounds


Other interactions of Myst4


  1. Querkopf, a MYST family histone acetyltransferase, is required for normal cerebral cortex development. Thomas, T., Voss, A.K., Chowdhury, K., Gruss, P. Development (2000) [Pubmed]
  2. Expression of myeloid differentiation antigens on normal and malignant myeloid cells. Griffin, J.D., Ritz, J., Nadler, L.M., Schlossman, S.F. J. Clin. Invest. (1981) [Pubmed]
  3. Expression of a constitutively active mutant of M-Ras in normal bone marrow is sufficient for induction of a malignant mastocytosis/mast cell leukemia, distinct from the histiocytosis/monocytic leukemia induced by expression of activated H-Ras. Guo, X., Schrader, K.A., Xu, Y., Schrader, J.W. Oncogene (2005) [Pubmed]
  4. Preparation of a monoclonal antibody against human monocyte lineage. Maruyama, S., Naito, T., Kakita, H., Kishimoto, S., Yamamura, Y., Kishimoto, T. J. Clin. Immunol. (1983) [Pubmed]
  5. Purification of a pluripotent neural stem cell from the adult mouse brain. Rietze, R.L., Valcanis, H., Brooker, G.F., Thomas, T., Voss, A.K., Bartlett, P.F. Nature (2001) [Pubmed]
  6. Expression of constitutively activated human c-Kit in Myb transformed early myeloid cells leads to factor independence, histiocytic differentiation, and tumorigenicity. Ferrao, P., Gonda, T.J., Ashman, L.K. Blood (1997) [Pubmed]
  7. Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins. Grill, B., Wilson, G.M., Zhang, K.X., Wang, B., Doyonnas, R., Quadroni, M., Schrader, J.W. J. Immunol. (2004) [Pubmed]
  8. Querkopf, a histone acetyltransferase, is essential for embryonic neurogenesis. Thomas, T., Voss, A.K. Front. Biosci. (2004) [Pubmed]
  9. The human monocyte-like cell line THP-1 expresses Fc gamma RI and Fc gamma RII. Fleit, H.B., Kobasiuk, C.D. J. Leukoc. Biol. (1991) [Pubmed]
  10. Synthesis and cytotoxicity of substituted ethyl 2-phenacyl-3-phenylpyrrole-4-carboxylates. Evans, M.A., Smith, D.C., Holub, J.M., Argenti, A., Hoff, M., Dalglish, G.A., Wilson, D.L., Taylor, B.M., Berkowitz, J.D., Burnham, B.S., Krumpe, K., Gupton, J.T., Scarlett, T.C., Durham Jr, R.W., Hall, I.H. Arch. Pharm. (Weinheim) (2003) [Pubmed]
  11. Vidarabine and 2-deoxycoformycin as antileukemic agents against monocytic leukemia. Honma, Y., Niitsu, N. Leuk. Lymphoma (2000) [Pubmed]
  12. Carcinogenicity of dimethoate. Reuber, M.D. Environmental research. (1984) [Pubmed]
  13. Constitutive overexpression of the c-fos gene in radiation-induced granulocytic leukemia in mice. Ishihara, H., Yoshida, K., Nemoto, K., Tsuneoka, K., Shikita, M. Radiat. Res. (1993) [Pubmed]
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