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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Critical Illness

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Disease relevance of Critical Illness


Psychiatry related information on Critical Illness


High impact information on Critical Illness


Chemical compound and disease context of Critical Illness


Biological context of Critical Illness


Anatomical context of Critical Illness

  • In conclusion, maintaining normoglycemia with intensive insulin therapy during critical illness protects the endothelium, likely in part via inhibition of excessive iNOS-induced NO release, and thereby contributes to prevention of organ failure and death [26].
  • Because critically ill patients show a marked suppression of T-cell and macrophage functions with a high susceptibility to infection, potential defects in the immunity/inflammation upregulating IL-12 IFN-gamma pathway were studied [27].
  • We find preliminary evidence that sucralfate is as efficacious as and more cost-effective than either cimetidine or antacids for prophylaxis of stress-related gastrointestinal tract bleeding in the critically ill ventilator-dependent patient [28].
  • These findings indicate that the prolonged administration of pharmcological doses of DA significantly reduced serum TSH levels and thyroid hormone secretion in normal and critically ill patients, most likely by a direct inhibition of pituitary TSH with a secondary effect on thyroid gland secretion [29].
  • VCAM-1-mediated leukocyte extravasation is implicated in several illnesses including atherosclerosis and multiple-organ failure in sepsis, and we hypothesize that enhanced expression of VCAM-1 may contribute to the detrimental effects of GH in critically ill patients [30].

Gene context of Critical Illness


Analytical, diagnostic and therapeutic context of Critical Illness


  1. A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance. Parrillo, J.E., Burch, C., Shelhamer, J.H., Parker, M.M., Natanson, C., Schuette, W. J. Clin. Invest. (1985) [Pubmed]
  2. Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Bellomo, R., Chapman, M., Finfer, S., Hickling, K., Myburgh, J. Lancet (2000) [Pubmed]
  3. Indomethacin and arterial oxygenation in critically ill patients with severe bacterial pneumonia. Bihari, D.J. Lancet (1987) [Pubmed]
  4. Fingerstick glucose determination in shock. Atkin, S.H., Dasmahapatra, A., Jaker, M.A., Chorost, M.I., Reddy, S. Ann. Intern. Med. (1991) [Pubmed]
  5. Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acidosis. A prospective, controlled clinical study. Cooper, D.J., Walley, K.R., Wiggs, B.R., Russell, J.A. Ann. Intern. Med. (1990) [Pubmed]
  6. Total vitamin C, ascorbic acid, and dehydroascorbic acid concentrations in plasma of critically ill patients. Schorah, C.J., Downing, C., Piripitsi, A., Gallivan, L., Al-Hazaa, A.H., Sanderson, M.J., Bodenham, A. Am. J. Clin. Nutr. (1996) [Pubmed]
  7. The stat laboratory: facilitating blood gas and biochemical measurements for the critically ill and injured. Weil, M.H., Michaels, S., Puri, V.K., Carlson, R.W. Am. J. Clin. Pathol. (1981) [Pubmed]
  8. Number needed to treat and cost of recombinant human erythropoietin to avoid one transfusion-related adverse event in critically ill patients. Shermock, K.M., Horn, E., Lipsett, P.A., Pronovost, P.J., Dorman, T. Crit. Care Med. (2005) [Pubmed]
  9. Melatonin: possible implications for the postoperative and critically ill patient. Bourne, R.S., Mills, G.H. Intensive care medicine. (2006) [Pubmed]
  10. Orally active growth hormone secretagogues: state of the art and clinical perspectives. Ghigo, E., Arvat, E., Camanni, F. Ann. Med. (1998) [Pubmed]
  11. Intensive insulin therapy in the critically ill patients. van den Berghe, G., Wouters, P., Weekers, F., Verwaest, C., Bruyninckx, F., Schetz, M., Vlasselaers, D., Ferdinande, P., Lauwers, P., Bouillon, R. N. Engl. J. Med. (2001) [Pubmed]
  12. A comparison of sucralfate and ranitidine for the prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care Trials Group. Cook, D., Guyatt, G., Marshall, J., Leasa, D., Fuller, H., Hall, R., Peters, S., Rutledge, F., Griffith, L., McLellan, A., Wood, G., Kirby, A. N. Engl. J. Med. (1998) [Pubmed]
  13. A computer-assisted management program for antibiotics and other antiinfective agents. Evans, R.S., Pestotnik, S.L., Classen, D.C., Clemmer, T.P., Weaver, L.K., Orme, J.F., Lloyd, J.F., Burke, J.P. N. Engl. J. Med. (1998) [Pubmed]
  14. Elevation of systemic oxygen delivery in the treatment of critically ill patients. Hayes, M.A., Timmins, A.C., Yau, E.H., Palazzo, M., Hinds, C.J., Watson, D. N. Engl. J. Med. (1994) [Pubmed]
  15. Persistent paralysis in critically ill patients after long-term administration of vecuronium. Segredo, V., Caldwell, J.E., Matthay, M.A., Sharma, M.L., Gruenke, L.D., Miller, R.D. N. Engl. J. Med. (1992) [Pubmed]
  16. Antacid versus cimetidine in preventing acute gastrointestinal bleeding. A randomized trial in 75 critically ill patients. Priebe, H.J., Skillman, J.J., Bushnell, L.S., Long, P.C., Silen, W. N. Engl. J. Med. (1980) [Pubmed]
  17. Total parenteral nutrition for critically ill patients. Weyandt, D., Karzai, W. JAMA (1999) [Pubmed]
  18. The use and clinical importance of a substrate-specific electrode for rapid determination of blood lactate concentrations. Aduen, J., Bernstein, W.K., Khastgir, T., Miller, J., Kerzner, R., Bhatiani, A., Lustgarten, J., Bassin, A.S., Davison, L., Chernow, B. JAMA (1994) [Pubmed]
  19. Identification of the critical oxygen delivery for anaerobic metabolism in critically ill septic and nonseptic humans. Ronco, J.J., Fenwick, J.C., Tweeddale, M.G., Wiggs, B.R., Phang, P.T., Cooper, D.J., Cunningham, K.F., Russell, J.A., Walley, K.R. JAMA (1993) [Pubmed]
  20. Free thyroxine levels in critically ill patients. Buehler, R.J., Sullivan, W.M. JAMA (1982) [Pubmed]
  21. Glutamine nutrition and metabolism: where do we go from here ? Neu, J., Shenoy, V., Chakrabarti, R. FASEB J. (1996) [Pubmed]
  22. Calcium-sensing receptor gene transcription is up-regulated by the proinflammatory cytokine, interleukin-1beta. Role of the NF-kappaB PATHWAY and kappaB elements. Canaff, L., Hendy, G.N. J. Biol. Chem. (2005) [Pubmed]
  23. Ciprofloxacin pharmacokinetics in critically ill trauma patients. Yuen, G.J., Drusano, G.L., Plaisance, K., Forrest, A., Caplan, E.S. Am. J. Med. (1989) [Pubmed]
  24. Bolus injection of cimetidine and hypotension in patients in the intensive care unit. Incidence and mechanisms. Kiowski, W., Frei, A. Arch. Intern. Med. (1987) [Pubmed]
  25. Cisapride improves gastric emptying in mechanically ventilated, critically ill patients. A randomized, double-blind trial. Heyland, D.K., Tougas, G., Cook, D.J., Guyatt, G.H. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  26. Intensive insulin therapy protects the endothelium of critically ill patients. Langouche, L., Vanhorebeek, I., Vlasselaers, D., Vander Perre, S., Wouters, P.J., Skogstrand, K., Hansen, T.K., Van den Berghe, G. J. Clin. Invest. (2005) [Pubmed]
  27. Inhibition of the defense system stimulating interleukin-12 interferon-gamma pathway during critical Illness. Ertel, W., Keel, M., Neidhardt, R., Steckholzer, U., Kremer, J.P., Ungethuem, U., Trentz, O. Blood (1997) [Pubmed]
  28. Prophylaxis of upper gastrointestinal tract bleeding in mechanically ventilated patients. A randomized study comparing the efficacy of sucralfate, cimetidine, and antacids. Cannon, L.A., Heiselman, D., Gardner, W., Jones, J. Arch. Intern. Med. (1987) [Pubmed]
  29. Prolonged dopamine administration and thyroid hormone economy in normal and critically ill subjects. Kaptein, E.M., Spencer, C.A., Kamiel, M.B., Nicoloff, J.T. J. Clin. Endocrinol. Metab. (1980) [Pubmed]
  30. Growth hormone increases vascular cell adhesion molecule 1 expression: in vivo and in vitro evidence. Hansen, T.K., Fisker, S., Dall, R., Ledet, T., Jørgensen, J.O., Rasmussen, L.M. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  31. Extracellular ubiquitin inhibits the TNF-alpha response to endotoxin in peripheral blood mononuclear cells and regulates endotoxin hyporesponsiveness in critical illness. Majetschak, M., Krehmeier, U., Bardenheuer, M., Denz, C., Quintel, M., Voggenreiter, G., Obertacke, U. Blood (2003) [Pubmed]
  32. Interleukin-1 receptor antagonist circulates in experimental inflammation and in human disease. Fischer, E., Van Zee, K.J., Marano, M.A., Rock, C.S., Kenney, J.S., Poutsiaka, D.D., Dinarello, C.A., Lowry, S.F., Moldawer, L.L. Blood (1992) [Pubmed]
  33. A paradoxical gender dissociation within the growth hormone/insulin-like growth factor I axis during protracted critical illness. Van den Berghe, G., Baxter, R.C., Weekers, F., Wouters, P., Bowers, C.Y., Veldhuis, J.D. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  34. The hypothalamic-pituitary-adrenal axis in critical illness: response to dexamethasone and corticotropin-releasing hormone. Reincke, M., Allolio, B., Würth, G., Winkelmann, W. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  35. Total parenteral nutrition in the critically ill patient: a meta-analysis. Heyland, D.K., MacDonald, S., Keefe, L., Drover, J.W. JAMA (1998) [Pubmed]
  36. Outcome and attributable mortality in critically Ill patients with bacteremia involving methicillin-susceptible and methicillin-resistant Staphylococcus aureus. Blot, S.I., Vandewoude, K.H., Hoste, E.A., Colardyn, F.A. Arch. Intern. Med. (2002) [Pubmed]
  37. Leptin levels in protracted critical illness: effects of growth hormone-secretagogues and thyrotropin-releasing hormone. Van den Berghe, G., Wouters, P., Carlsson, L., Baxter, R.C., Bouillon, R., Bowers, C.Y. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  38. Pharmacokinetics of meropenem in critically ill patients with acute renal failure undergoing continuous venovenous hemofiltration. Tegeder, I., Neumann, F., Bremer, F., Brune, K., Lötsch, J., Geisslinger, G. Clin. Pharmacol. Ther. (1999) [Pubmed]
  39. Copper, selenium, zinc, and thiamine balances during continuous venovenous hemodiafiltration in critically ill patients. Berger, M.M., Shenkin, A., Revelly, J.P., Roberts, E., Cayeux, M.C., Baines, M., Chioléro, R.L. Am. J. Clin. Nutr. (2004) [Pubmed]
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