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Gene Review

ZFP36L2  -  ZFP36 ring finger protein-like 2

Homo sapiens

Synonyms: BRF2, Butyrate response factor 2, EGF-response factor 2, ERF-2, ERF2, ...
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High impact information on ZFP36L2

  • It was shown that the LTR sequences of two subfamilies harbor a specific binding site for a complex consisting of at least three proteins, ERF1, ERF2 and ERF3 of 98, 91 and 88 kDa apparent molecular mass, respectively [1].
  • Forty-nine of these loci were localized into expected chromosome regions according to Zoo-FISH data, whereas four loci--ALPL, CDC20, ERF-2, and Fc(Mv)23617--were mapped out of expected conserved regions [2].
  • These data suggest TIS11D as a candidate p53 target gene that may be part of the network of genes responsible for p53-dependent apoptosis [3].
  • Inducible expression of TIS11D resulted in inhibition of cell proliferation and apoptosis [3].

Analytical, diagnostic and therapeutic context of ZFP36L2


  1. Long terminal repeats of human endogenous retrovirus K family (HERV-K) specifically bind host cell nuclear proteins. Akopov, S.B., Nikolaev, L.G., Khil, P.P., Lebedev, Y.B., Sverdlov, E.D. FEBS Lett. (1998) [Pubmed]
  2. Mapping of 53 loci in American mink (Mustela vison). Kuznetsov, S.B., Matveeva, N.M., Murphy, W.J., O'Brien, S.J., Serov, O.L. J. Hered. (2003) [Pubmed]
  3. TIS11D is a candidate pro-apoptotic p53 target gene. Jackson, R.S., Cho, Y.J., Liang, P. Cell Cycle (2006) [Pubmed]
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