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ZFP36L1  -  ZFP36 ring finger protein-like 1

Homo sapiens

Synonyms: BERG36, BRF1, Berg36, Butyrate response factor 1, EGF-response factor 1, ...
 
 
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Disease relevance of ZFP36L1

 

High impact information on ZFP36L1

  • The accumulation of ARE-mRNAs in PBs is strongly enhanced when the mRNA decay machinery is rendered limiting by mRNA decay enzyme depletion or TTP/BRF-1 overexpression [6].
  • Furthermore, hypertrophic stimulation increases expression of the essential TFIIIB subunit Brf1, an effect not seen when fibroblasts proliferate [1].
  • Finally, we show that arsenite promotes the delayed association of PMR1 with SGs under conditions which cause tristetraprolin and butyrate response factor 1, proteins that facilitate exonucleolytic mRNA, to exit SGs [7].
  • However, IL-4 did protect Ramos cells from apoptosis induced by calcium ionophore and this effect was accompanied by inhibition of ionophore-induced expression of an immediate early gene encoding a 36-kDa zinc-finger protein, Berg36 [8].
  • It was shown that the LTR sequences of two subfamilies harbor a specific binding site for a complex consisting of at least three proteins, ERF1, ERF2 and ERF3 of 98, 91 and 88 kDa apparent molecular mass, respectively [9].
 

Biological context of ZFP36L1

  • We have used macroarrays to identify zinc finger protein butyrate response factor-1 (BRF1) as a novel PTH regulated gene in clonal and normal osteoblasts of human and rodent origin [10].
  • Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1 [11].
  • Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signalling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36 [12].
  • Fragments encoding the middle portion and the 3' end were discovered in the Bombyx mori Genome Project "Silkbase" collection through sequence homology with human BRF1, and the fragment encoding the N-terminus was isolated in our laboratory using the 5' RACE method [13].
 

Anatomical context of ZFP36L1

  • In mouse calvarial osteoblasts, BRF1 mRNA levels are upregulated by PTH(1-84) and reduced in response to bone morphogenetic protein 2 (BMP-2) [10].
 

Associations of ZFP36L1 with chemical compounds

  • Two other short-chain fatty acids, propionate and acetate, have no detectable effects on BRF1 or BRF2 transcription [14].
 

Other interactions of ZFP36L1

References

  1. Regulation of RNA polymerase III transcription during hypertrophic growth. Goodfellow, S.J., Innes, F., Derblay, L.E., MacLellan, W.R., Scott, P.H., White, R.J. EMBO J. (2006) [Pubmed]
  2. Simian virus 40 large T antigen interacts with human TFIIB-related factor and small nuclear RNA-activating protein complex for transcriptional activation of TATA-containing polymerase III promoters. Damania, B., Mital, R., Alwine, J.C. Mol. Cell. Biol. (1998) [Pubmed]
  3. Butyrate response factor 1 enhances cisplatin sensitivity in human head and neck squamous cell carcinoma cell lines. Lee, S.K., Kim, S.B., Kim, J.S., Moon, C.H., Han, M.S., Lee, B.J., Chung, D.K., Min, Y.J., Park, J.H., Choi, D.H., Cho, H.R., Park, S.K., Park, J.W. Int. J. Cancer (2005) [Pubmed]
  4. Identification of RAS-mitogen-activated protein kinase signaling pathway modulators in an ERF1 redistribution screen. Grånäs, C., Lundholt, B.K., Loechel, F., Pedersen, H.C., Bjørn, S.P., Linde, V., Krogh-Jensen, C., Nielsen, E.M., Praestegaard, M., Nielsen, S.J. Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening. (2006) [Pubmed]
  5. Targets of 17beta-oestradiol-induced apoptosis in colon cancer cells: a mechanism for the protective effects of hormone replacement therapy? Qiu, Y., Langman, M.J., Eggo, M.C. J. Endocrinol. (2004) [Pubmed]
  6. TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements. Franks, T.M., Lykke-Andersen, J. Genes Dev. (2007) [Pubmed]
  7. Polysome-Bound Endonuclease PMR1 Is Targeted to Stress Granules via Stress-Specific Binding to TIA-1. Yang, F., Peng, Y., Murray, E.L., Otsuka, Y., Kedersha, N., Schoenberg, D.R. Mol. Cell. Biol. (2006) [Pubmed]
  8. Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36. Ning, Z.Q., Norton, J.D., Li, J., Murphy, J.J. Eur. J. Immunol. (1996) [Pubmed]
  9. Long terminal repeats of human endogenous retrovirus K family (HERV-K) specifically bind host cell nuclear proteins. Akopov, S.B., Nikolaev, L.G., Khil, P.P., Lebedev, Y.B., Sverdlov, E.D. FEBS Lett. (1998) [Pubmed]
  10. Butyrate response factor 1 is regulated by parathyroid hormone and bone morphogenetic protein-2 in osteoblastic cells. Reppe, S., Olstad, O.K., Rian, E., Gautvik, V.T., Gautvik, K.M., Jemtland, R. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  11. Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1. Lykke-Andersen, J., Wagner, E. Genes Dev. (2005) [Pubmed]
  12. Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signalling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36. Ning, Z.Q., Norton, J.D., Li, J., Murphy, J.J. Biochem. Soc. Trans. (1997) [Pubmed]
  13. Cloning of a putative Bombyx mori TFIIB-related factor (BRF). Martinez, M.J., Sprague, K.U. Arch. Insect Biochem. Physiol. (2003) [Pubmed]
  14. Differential effects of sodium butyrate on the transcription of the human TIS11 family of early-response genes in colorectal cancer cells. Maclean, K.N., McKay, I.A., Bustin, S.A. Br. J. Biomed. Sci. (1998) [Pubmed]
  15. Expression of butyrate response factor 1 in HTLV-1-transformed cells and its transactivation by tax protein. Li, B., Fink, T., Ebbesen, P., Liu, X.D., Zachar, V. Arch. Virol. (2003) [Pubmed]
 
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