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Gene Review:

Kdelr1 - KDEL (Lys-Asp-Glu-Leu) endoplasmic...

Mus musculus

Synonyms: 8030486F04Rik, AW215843, ER lumen protein-retaining receptor 1, Erd2.1, KDEL endoplasmic reticulum protein retention receptor 1, ...

Arendt, C.W. et al., Hamada, H. et al., Sauk, J.J. et al.

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Disease relevance of Kdelr1

We found that the mutant KDEL receptor sensitized cells to ER stress and that the mutant mice developed dilated cardiomyopathy [1].

High impact information on Kdelr1

Dilated cardiomyopathy caused by aberrant endoplasmic reticulum quality control in mutant KDEL receptor transgenic mice [1].
Since the beta-subunit, which contains a C-terminal His-Asp-Glu-Leu (HDEL) motif, may function to link the catalytic subunit to the KDEL receptor as a retrieval mechanism, we sought to map the regions of the mouse beta-subunit protein responsible for mediating the association with the alpha-subunit [2].
Hsp47 binds to the KDEL receptor and cell surface expression is modulated by cytoplasmic and endosomal pH [3].

Other interactions of Kdelr1

In this paper, we report that erd2P, the KDEL receptor, is distributed, coprecipitates with, and binds to Hsp47 [3].

References

Dilated cardiomyopathy caused by aberrant endoplasmic reticulum quality control in mutant KDEL receptor transgenic mice. Hamada, H., Suzuki, M., Yuasa, S., Mimura, N., Shinozuka, N., Takada, Y., Suzuki, M., Nishino, T., Nakaya, H., Koseki, H., Aoe, T. Mol. Cell. Biol. (2004) [Pubmed]
Two distinct domains of the beta-subunit of glucosidase II interact with the catalytic alpha-subunit. Arendt, C.W., Ostergaard, H.L. Glycobiology (2000) [Pubmed]
Hsp47 binds to the KDEL receptor and cell surface expression is modulated by cytoplasmic and endosomal pH. Sauk, J.J., Norris, K., Hebert, C., Ordóñez, J., Reynolds, M. Connect. Tissue Res. (1998) [Pubmed]

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AgaP_AGAP010224	Anopheles gambiae str. PEST
AgaP_AGAP012756	Anopheles gambiae str. PEST
ERD2	Arabidopsis thaliana
AGOS_AGL323C	Ashbya gossypii ATCC 10895
KDELR1	Bos taurus
KDELR1	Canis lupus familiaris
KdelR	Drosophila melanogaster
KDELR1	Homo sapiens
KLLA0E05611g	Kluyveromyces lactis NRRL Y-1140
KDELR1	Macaca mulatta
MGG_16126	Magnaporthe oryzae 70-15
NCU06771	Neurospora crassa OR74A
Os05g0529300	Oryza sativa Japonica Group
KDELR1	Pan troglodytes
Kdelr1	Rattus norvegicus
ERD2	Saccharomyces cerevisiae S288c
erd2	Schizosaccharomyces pombe 972h-
kdelr2	Xenopus (Silurana) tropicalis

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