Gene Review:
KDELR1 - KDEL (Lys-Asp-Glu-Leu) endoplasmic...
Homo sapiens
Synonyms:
ER lumen protein-retaining receptor 1, ERD2, ERD2.1, HDEL, KDEL endoplasmic reticulum protein retention receptor 1, ...
- Anterograde flow of cargo across the golgi stack potentially mediated via bidirectional "percolating" COPI vesicles. Orci, L., Ravazzola, M., Volchuk, A., Engel, T., Gmachl, M., Amherdt, M., Perrelet, A., Sollner, T.H., Rothman, J.E. Proc. Natl. Acad. Sci. U.S.A. (2000)
- The KDEL retrieval system is exploited by Pseudomonas exotoxin A, but not by Shiga-like toxin-1, during retrograde transport from the Golgi complex to the endoplasmic reticulum. Jackson, M.E., Simpson, J.C., Girod, A., Pepperkok, R., Roberts, L.M., Lord, J.M. J. Cell. Sci. (1999)
- Purification and characterization of the human KDEL receptor. Scheel, A.A., Pelham, H.R. Biochemistry (1996)
- Ligand-induced redistribution of a human KDEL receptor from the Golgi complex to the endoplasmic reticulum. Lewis, M.J., Pelham, H.R. Cell (1992)
- A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1. Hsu, V.W., Shah, N., Klausner, R.D. Cell (1992)
- A human homologue of the yeast HDEL receptor. Lewis, M.J., Pelham, H.R. Nature (1990)
- An early step in Pseudomonas exotoxin action is removal of the terminal lysine residue, which allows binding to the KDEL receptor. Hessler, J.L., Kreitman, R.J. Biochemistry (1997)
- Importance of the glutamate residue of KDEL in increasing the cytotoxicity of Pseudomonas exotoxin derivatives and for increased binding to the KDEL receptor. Kreitman, R.J., Pastan, I. Biochem. J. (1995)
- The KDEL receptor modulates the endoplasmic reticulum stress response through mitogen-activated protein kinase signaling cascades. Yamamoto, K., Hamada, H., Shinkai, H., Kohno, Y., Koseki, H., Aoe, T. J. Biol. Chem. (2003)
- KDEL receptor expression is not coordinatedly up-regulated with ER stress-induced reticuloplasmin expression in HeLa cells. Llewellyn, D.H., Roderick, H.L., Rose, S. Biochem. Biophys. Res. Commun. (1997)
- Protein disulfide isomerase and newly synthesized procollagen chains form higher-order structures in the lumen of the endoplasmic reticulum. Kellokumpu, S., Suokas, M., Risteli, L., Myllylä, R. J. Biol. Chem. (1997)
- Endoplasmic reticulum glucosidase II is composed of a catalytic subunit, conserved from yeast to mammals, and a tightly bound noncatalytic HDEL-containing subunit. Trombetta, E.S., Simons, J.F., Helenius, A. J. Biol. Chem. (1996)
- The nuclear envelope serves as an intermediary between the ER and Golgi complex in the intracellular parasite Toxoplasma gondii. Hager, K.M., Striepen, B., Tilney, L.G., Roos, D.S. J. Cell. Sci. (1999)
- Mutational analysis of the human KDEL receptor: distinct structural requirements for Golgi retention, ligand binding and retrograde transport. Townsley, F.M., Wilson, D.W., Pelham, H.R. EMBO J. (1993)
- Protein recycling from the Golgi apparatus to the endoplasmic reticulum in plants and its minor contribution to calreticulin retention. Pagny, S., Cabanes-Macheteau, M., Gillikin, J.W., Leborgne-Castel, N., Lerouge, P., Boston, R.S., Faye, L., Gomord, V. Plant Cell (2000)
- Modulation of intracellular transport by transported proteins: insight from regulation of COPI-mediated transport. Aoe, T., Lee, A.J., van Donselaar, E., Peters, P.J., Hsu, V.W. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Transmembrane topology of the mammalian KDEL receptor. Singh, P., Tang, B.L., Wong, S.H., Hong, W. Mol. Cell. Biol. (1993)
- The mammalian protein (rbet1) homologous to yeast Bet1p is primarily associated with the pre-Golgi intermediate compartment and is involved in vesicular transport from the endoplasmic reticulum to the Golgi apparatus. Zhang, T., Wong, S.H., Tang, B.L., Xu, Y., Peter, F., Subramaniam, V.N., Hong, W. J. Cell Biol. (1997)
- Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members. Füllekrug, J., Suganuma, T., Tang, B.L., Hong, W., Storrie, B., Nilsson, T. Mol. Biol. Cell (1999)
- Retention and retrieval: both mechanisms cooperate to maintain calreticulin in the endoplasmic reticulum. Sönnichsen, B., Füllekrug, J., Nguyen Van, P., Diekmann, W., Robinson, D.G., Mieskes, G. J. Cell. Sci. (1994)
- KDEL motif interacts with a specific sequence in mammalian erd2 receptor. Janson, I.M., Toomik, R., O'Farrell, F., Ek, P. Biochem. Biophys. Res. Commun. (1998)
- The KDEL receptor regulates a GTPase-activating protein for ADP-ribosylation factor 1 by interacting with its non-catalytic domain. Aoe, T., Huber, I., Vasudevan, C., Watkins, S.C., Romero, G., Cassel, D., Hsu, V.W. J. Biol. Chem. (1999)
- Regulation of protein transport from the Golgi complex to the endoplasmic reticulum by CDC42 and N-WASP. Luna, A., Matas, O.B., Martínez-Menárguez, J.A., Mato, E., Durán, J.M., Ballesta, J., Way, M., Egea, G. Mol. Biol. Cell (2002)
- A single C-terminal peptide segment mediates both membrane association and localization of lysyl hydroxylase in the endoplasmic reticulum. Suokas, M., Myllyla, R., Kellokumpu, S. J. Biol. Chem. (2000)
- Profile-based data base scanning for animal L-type lectins and characterization of VIPL, a novel VIP36-like endoplasmic reticulum protein. Nufer, O., Mitrovic, S., Hauri, H.P. J. Biol. Chem. (2003)
- Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum. Girod, A., Storrie, B., Simpson, J.C., Johannes, L., Goud, B., Roberts, L.M., Lord, J.M., Nilsson, T., Pepperkok, R. Nat. Cell Biol. (1999)
- Identification of amino acids in the binding pocket of the human KDEL receptor. Scheel, A.A., Pelham, H.R. J. Biol. Chem. (1998)
- Endoplasmic reticulum resident proteins of normal human dermal fibroblasts are the major targets for oxidative stress induced by hydrogen peroxide. van der Vlies, D., Pap, E.H., Post, J.A., Celis, J.E., Wirtz, K.W. Biochem. J. (2002)
- Long-lasting aberrant tubulovesicular membrane inclusions accumulate in developing motoneurons after a sublethal excitotoxic insult: a possible model for neuronal pathology in neurodegenerative disease. Tarabal, O., Calderó, J., Lladó, J., Oppenheim, R.W., Esquerda, J.E. J. Neurosci. (2001)